The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, the mitotic cycle, and oncogenic transformation. This PTP contains a PEST motif, which often serves as a protein-protein interaction domain, and may be related to protein intracellular half-live. This protein can differentially dephosphorylate autophosphorylated tyrosine kinases that are overexpressed in tumor tissues, and it appears to regulate HER2, a member of the epidermal growth factor receptor family of receptor tyrosine kinases. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2008]
Transcription factors with Perturb-seq knockdown data for PTPN18. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PTPN18 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PTPN18, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:130,144,783–130,145,418 | 210.9 kb | Distal (>10kb) Multiome | 89 | |
| chr2:130,181,118–130,182,559 | 174.1 kb | Distal (>10kb) Multiome | 790 | |
| chr2:130,288,447–130,288,984 | 67.3 kb | Distal (>10kb) Multiome | 232 | |
| chr2:130,327,383–130,328,425 | 28.2 kb | Distal (>10kb) Multiome | 215 | |
| chr2:130,336,899–130,337,857 | 18.7 kb | Distal (>10kb) Multiome | 861 | |
| chr2:130,341,623–130,343,538 | 13.3 kb | Distal (>10kb) Multiome | 1109 | |
| chr2:130,355,375–130,356,704 | 34 bp | At TSS Multiome | 816 | |
| chr2:130,371,871–130,373,243 | 16.5 kb | Distal (>10kb) Multiome | 651 | |
| chr2:130,391,075–130,391,923 | 35.5 kb | Distal (>10kb) Multiome | 609 |
Genomic view of the PTPN18 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.