Protein phosphatase 2A is one of the four major Ser/Thr phosphatases and is implicated in the negative control of cell growth and division. Protein phosphatase 2A holoenzymes are heterotrimeric proteins composed of a structural subunit A, a catalytic subunit C, and a regulatory subunit B. The regulatory subunit is encoded by a diverse set of genes that have been grouped into the B/PR55, B'/PR61, and B''/PR72 families. These different regulatory subunits confer distinct enzymatic specificities and intracellular localizations to the holozenzyme. The product of this gene belongs to the B' family. This gene encodes a specific phosphotyrosyl phosphatase activator of the dimeric form of protein phosphatase 2A. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for PTPA. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PTPA upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PTPA, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:128,818,208–128,819,406 | 293.0 kb | Distal (>10kb) Multiome | 839 | |
| chr9:128,829,505–128,830,189 | 281.6 kb | Distal (>10kb) Multiome | 782 | |
| chr9:128,881,863–128,882,454 | 229.3 kb | Distal (>10kb) Multiome | 777 | |
| chr9:128,921,941–128,922,727 | 189.1 kb | Distal (>10kb) Multiome | 378 | |
| chr9:128,947,329–128,947,815 | 163.8 kb | Distal (>10kb) Multiome | 865 | |
| chr9:129,027,821–129,028,677 | 83.0 kb | Distal (>10kb) Multiome | 639 | |
| chr9:129,036,276–129,036,937 | 74.9 kb | Distal (>10kb) Multiome | 736 | |
| chr9:129,080,488–129,081,502 | 30.4 kb | Distal (>10kb) Multiome | 755 | |
| chr9:129,110,314–129,111,708 | 351 bp | At TSS Multiome | 881 | |
| chr9:129,139,248–129,139,448 | at TSS | At TSS | 427 | |
| chr9:129,177,207–129,178,809 | 66.9 kb | Distal (>10kb) Multiome | 824 | |
| chr9:129,208,459–129,208,914 | 97.3 kb | Distal (>10kb) Multiome | 108 | |
| chr9:129,334,082–129,334,794 | 223.0 kb | Distal (>10kb) Multiome | 928 | |
| chr9:129,413,561–129,414,426 | 302.4 kb | Distal (>10kb) Multiome | 753 | |
| chr9:129,495,758–129,497,403 | 385.5 kb | Distal (>10kb) Multiome HiCAR | 973 | |
| chr9:129,610,548–129,611,334 | 499.5 kb | Distal (>10kb) Multiome HiCAR | 630 | |
| chr9:129,626,055–129,626,580 | 514.8 kb | Distal (>10kb) Multiome HiCAR | 825 |
Genomic view of the PTPA locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.