This gene encodes a protein that was found to be overexpressed in prostate adenocarcinomas. The encoded protein was found to interact with the lipid raft protein flotillin-1 and shuttle it from the cytoplasm to the nucleus in a cell cycle dependent manner. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Feb 2015]
Transcription factors with Perturb-seq knockdown data for PTOV1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PTOV1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PTOV1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:49,555,629–49,557,180 | 294.9 kb | Distal (>10kb) Multiome | 294 | |
| chr19:49,580,125–49,580,813 | 270.4 kb | Distal (>10kb) Multiome | 848 | |
| chr19:49,589,601–49,594,008 | 257.5 kb | Distal (>10kb) Multiome | 994 | |
| chr19:49,638,063–49,638,728 | 212.7 kb | Distal (>10kb) Multiome | 237 | |
| chr19:49,639,671–49,642,787 | 210.6 kb | Distal (>10kb) Multiome | 1067 | |
| chr19:49,664,165–49,665,096 | 186.5 kb | Distal (>10kb) Multiome | 679 | |
| chr19:49,665,345–49,666,430 | 185.1 kb | Distal (>10kb) Multiome | 721 | |
| chr19:49,672,105–49,672,787 | 178.6 kb | Distal (>10kb) Multiome | 625 | |
| chr19:49,676,058–49,678,754 | 174.1 kb | Distal (>10kb) Multiome | 1033 | |
| chr19:49,680,433–49,681,147 | 170.2 kb | Distal (>10kb) Multiome | 435 | |
| chr19:49,690,485–49,691,761 | 159.9 kb | Distal (>10kb) Multiome | 327 | |
| chr19:49,746,188–49,746,748 | 104.6 kb | Distal (>10kb) Multiome | 283 | |
| chr19:49,766,231–49,767,440 | 84.3 kb | Distal (>10kb) Multiome | 718 | |
| chr19:49,802,146–49,802,787 | 48.5 kb | Distal (>10kb) Multiome | 200 | |
| chr19:49,805,226–49,805,871 | 45.5 kb | Distal (>10kb) Multiome | 245 | |
| chr19:49,808,201–49,809,746 | 42.1 kb | Distal (>10kb) Multiome | 509 | |
| chr19:49,812,926–49,813,834 | 37.5 kb | Distal (>10kb) Multiome | 650 | |
| chr19:49,817,356–49,818,721 | 32.8 kb | Distal (>10kb) Multiome | 784 | |
| chr19:49,850,394–49,852,067 | 126 bp | At TSS Multiome | 862 | |
| chr19:49,866,817–49,868,124 | 16.4 kb | Distal (>10kb) Multiome | 874 | |
| chr19:49,869,068–49,870,398 | 18.6 kb | Distal (>10kb) Multiome | 832 | |
| chr19:49,875,842–49,878,576 | 26.7 kb | Distal (>10kb) Multiome | 1153 | |
| chr19:49,889,853–49,891,381 | 39.5 kb | Distal (>10kb) Multiome | 640 | |
| chr19:49,928,884–49,930,473 | 78.9 kb | Distal (>10kb) Multiome | 1141 | |
| chr19:49,987,157–49,987,669 | 136.3 kb | Distal (>10kb) Multiome | 1095 | |
| chr19:50,024,875–50,026,285 | 174.7 kb | Distal (>10kb) Multiome | 1137 | |
| chr19:50,147,523–50,148,432 | 297.1 kb | Distal (>10kb) Multiome | 615 |
Genomic view of the PTOV1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.