This gene encodes an enzyme that converts prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2). This protein functions as a co-chaperone with heat shock protein 90 (HSP90), localizing to response elements in DNA and disrupting transcriptional activation complexes. Alternative splicing results in multiple transcript variants. There are multiple pseudogenes of this gene on several different chromosomes. [provided by RefSeq, Feb 2016]
Transcription factors with Perturb-seq knockdown data for PTGES3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PTGES3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PTGES3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:56,448,848–56,449,756 | 239.0 kb | Distal (>10kb) Multiome | 920 | |
| chr12:56,468,239–56,468,840 | 219.7 kb | Distal (>10kb) Multiome | 907 | |
| chr12:56,487,633–56,488,590 | 200.0 kb | Distal (>10kb) Multiome | 784 | |
| chr12:56,629,725–56,630,674 | 57.9 kb | Distal (>10kb) Multiome | 759 | |
| chr12:56,633,838–56,637,505 | 53.9 kb | Distal (>10kb) Multiome | 1037 | |
| chr12:56,645,530–56,646,466 | 42.1 kb | Distal (>10kb) Multiome HiCAR | 902 | |
| chr12:56,687,276–56,689,898 | 1.4 kb | Proximal (<10kb) Multiome | 1162 | |
| chr12:56,724,695–56,725,713 | 37.0 kb | Distal (>10kb) Multiome | 972 | |
| chr12:56,751,814–56,752,566 | 64.0 kb | Distal (>10kb) Multiome | 765 |
Genomic view of the PTGES3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.