The protein encoded by this gene is a membrane-associated prostaglandin E synthase, which catalyzes the conversion of prostaglandin H2 to prostaglandin E2. This protein also has been shown to activate the transcription regulated by a gamma-interferon-activated transcription element (GATE). Multiple transcript variants have been found for this gene. [provided by RefSeq, Jun 2009]
Transcription factors with Perturb-seq knockdown data for PTGES2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PTGES2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PTGES2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:127,828,234–127,829,024 | 299.5 kb | Distal (>10kb) Multiome | 521 | |
| chr9:127,877,282–127,878,202 | 250.4 kb | Distal (>10kb) Multiome | 531 | |
| chr9:127,897,316–127,897,796 | 230.6 kb | Distal (>10kb) Multiome | 437 | |
| chr9:127,898,861–127,900,094 | 228.5 kb | Distal (>10kb) Multiome | 630 | |
| chr9:127,916,386–127,917,505 | 211.0 kb | Distal (>10kb) Multiome | 474 | |
| chr9:127,926,756–127,928,574 | 200.6 kb | Distal (>10kb) Multiome | 411 | |
| chr9:127,930,321–127,931,068 | 197.4 kb | Distal (>10kb) Multiome | 537 | |
| chr9:127,937,578–127,938,244 | 190.2 kb | Distal (>10kb) Multiome | 674 | |
| chr9:127,955,445–127,955,915 | 172.5 kb | Distal (>10kb) Multiome | 540 | |
| chr9:127,980,172–127,981,966 | 147.0 kb | Distal (>10kb) Multiome | 691 | |
| chr9:128,033,544–128,034,106 | 94.2 kb | Distal (>10kb) Multiome | 69 | |
| chr9:128,034,940–128,035,527 | 92.8 kb | Distal (>10kb) Multiome | 480 | |
| chr9:128,066,577–128,068,774 | 60.7 kb | Distal (>10kb) Multiome | 874 | |
| chr9:128,097,872–128,098,910 | 29.7 kb | Distal (>10kb) Multiome | 712 | |
| chr9:128,117,658–128,118,328 | 10.3 kb | Distal (>10kb) Multiome | 640 | |
| chr9:128,127,314–128,128,793 | 158 bp | At TSS Multiome | 899 | |
| chr9:128,159,371–128,160,928 | 32.0 kb | Distal (>10kb) Multiome | 824 | |
| chr9:128,191,300–128,192,050 | 63.5 kb | Distal (>10kb) Multiome | 865 | |
| chr9:128,203,004–128,204,704 | 76.3 kb | Distal (>10kb) Multiome | 690 | |
| chr9:128,218,656–128,219,107 | 90.8 kb | Distal (>10kb) Multiome | 410 | |
| chr9:128,250,012–128,251,099 | 122.4 kb | Distal (>10kb) Multiome | 353 | |
| chr9:128,275,636–128,276,535 | 147.9 kb | Distal (>10kb) Multiome | 728 | |
| chr9:128,322,183–128,322,933 | 194.5 kb | Distal (>10kb) Multiome | 962 | |
| chr9:128,340,070–128,341,161 | 212.4 kb | Distal (>10kb) Multiome | 803 | |
| chr9:128,364,858–128,365,437 | 237.0 kb | Distal (>10kb) Multiome | 442 | |
| chr9:128,420,259–128,421,260 | 292.6 kb | Distal (>10kb) Multiome | 701 |
Genomic view of the PTGES2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.