The protein encoded by this gene binds to intronic polypyrimidine clusters in pre-mRNA molecules and is implicated in controlling the assembly of other splicing-regulatory proteins. This protein is very similar to the polypyrimidine tract binding protein (PTB) but most of its isoforms are expressed primarily in the brain. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
Transcription factors with Perturb-seq knockdown data for PTBP2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PTBP2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PTBP2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:96,087,725–96,088,461 | 633.8 kb | Distal (>10kb) Multiome HiCAR | 152 | |
| chr1:96,259,180–96,259,785 | 462.2 kb | Distal (>10kb) Multiome HiCAR | 142 | |
| chr1:96,475,023–96,475,918 | 246.2 kb | Distal (>10kb) Multiome | 193 | |
| chr1:96,715,315–96,715,972 | 6.1 kb | Proximal (<10kb) Multiome | 204 | |
| chr1:96,721,134–96,722,725 | 40 bp | At TSS Multiome | 738 | |
| chr1:96,845,384–96,846,141 | 124.0 kb | Distal (>10kb) Multiome | 211 |
Genomic view of the PTBP2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.