Predicted to enable kinase activity and tRNA binding activity. Predicted to be involved in translation. Predicted to act upstream of or within selenocysteine incorporation. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for PSTK. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PSTK upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PSTK, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:122,683,538–122,684,537 | 296.5 kb | Distal (>10kb) Multiome | 21 | |
| chr10:122,875,885–122,876,836 | 104.1 kb | Distal (>10kb) Multiome | 128 | |
| chr10:122,877,140–122,877,717 | 102.9 kb | Distal (>10kb) Multiome | 112 | |
| chr10:122,879,124–122,880,264 | 100.6 kb | Distal (>10kb) Multiome | 712 | |
| chr10:122,953,726–122,954,686 | 26.1 kb | Distal (>10kb) Multiome | 995 | |
| chr10:122,980,093–122,981,015 | 148 bp | At TSS Multiome | 874 | |
| chr10:122,981,244–122,981,387 | 844 bp | At TSS | 82 | |
| chr10:123,007,898–123,009,768 | 28.5 kb | Distal (>10kb) Multiome | 911 | |
| chr10:123,132,736–123,133,704 | 152.8 kb | Distal (>10kb) Multiome | 384 | |
| chr10:123,135,104–123,137,885 | 156.9 kb | Distal (>10kb) Multiome | 563 | |
| chr10:123,139,520–123,140,375 | 159.6 kb | Distal (>10kb) Multiome | 456 | |
| chr10:123,147,570–123,148,872 | 167.7 kb | Distal (>10kb) Multiome | 310 | |
| chr10:123,150,788–123,151,726 | 170.8 kb | Distal (>10kb) Multiome | 224 | |
| chr10:123,153,975–123,155,184 | 173.9 kb | Distal (>10kb) Multiome | 787 |
Genomic view of the PSTK locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.