This gene encodes a proline-rich protein that is a target for regulation by the tumor suppressor protein p53. The encoded protein plays an important role in mitosis by recruiting and regulating microtubule depolymerases that destabalize microtubules. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Apr 2014]
Transcription factors with Perturb-seq knockdown data for PSRC1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PSRC1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PSRC1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:109,041,106–109,042,646 | 241.0 kb | Distal (>10kb) Multiome | 792 | |
| chr1:109,075,733–109,076,324 | 207.1 kb | Distal (>10kb) Multiome | 864 | |
| chr1:109,090,360–109,091,274 | 192.3 kb | Distal (>10kb) Multiome | 1016 | |
| chr1:109,099,660–109,100,771 | 183.0 kb | Distal (>10kb) Multiome | 1149 | |
| chr1:109,112,499–109,113,189 | 170.3 kb | Distal (>10kb) Multiome | 536 | |
| chr1:109,113,744–109,114,449 | 168.9 kb | Distal (>10kb) Multiome | 236 | |
| chr1:109,213,499–109,214,619 | 69.2 kb | Distal (>10kb) Multiome | 770 | |
| chr1:109,229,475–109,230,215 | 53.3 kb | Distal (>10kb) Multiome | 221 | |
| chr1:109,240,604–109,241,116 | 42.1 kb | Distal (>10kb) Multiome | 391 | |
| chr1:109,249,055–109,250,364 | 33.6 kb | Distal (>10kb) Multiome | 527 | |
| chr1:109,263,250–109,264,042 | 19.4 kb | Distal (>10kb) Multiome | 767 | |
| chr1:109,277,486–109,277,927 | 5.2 kb | Proximal (<10kb) | 518 | |
| chr1:109,282,693–109,283,858 | 107 bp | At TSS Multiome | 850 | |
| chr1:109,306,995–109,308,024 | 24.5 kb | Distal (>10kb) Multiome | 425 | |
| chr1:109,397,369–109,398,671 | 114.9 kb | Distal (>10kb) Multiome | 654 | |
| chr1:109,425,842–109,427,054 | 143.4 kb | Distal (>10kb) Multiome | 922 | |
| chr1:109,466,294–109,467,385 | 183.5 kb | Distal (>10kb) Multiome | 452 | |
| chr1:109,483,147–109,484,806 | 200.8 kb | Distal (>10kb) Multiome | 1031 | |
| chr1:109,493,695–109,494,597 | 211.0 kb | Distal (>10kb) Multiome | 842 | |
| chr1:109,498,180–109,498,608 | 215.3 kb | Distal (>10kb) Multiome | 178 | |
| chr1:109,509,196–109,510,011 | 226.5 kb | Distal (>10kb) Multiome | 448 | |
| chr1:109,532,157–109,533,159 | 249.6 kb | Distal (>10kb) Multiome | 517 | |
| chr1:109,548,385–109,549,096 | 265.5 kb | Distal (>10kb) Multiome | 855 |
Genomic view of the PSRC1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.