The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. This gene encodes a member of the proteasome subunit S3 family that functions as one of the non-ATPase subunits of the 19S regulator lid. Single nucleotide polymorphisms in this gene are associated with neutrophil count. [provided by RefSeq, Jul 2012]
Transcription factors with Perturb-seq knockdown data for PSMD3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PSMD3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PSMD3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:39,687,710–39,688,437 | 292.8 kb | Distal (>10kb) Multiome | 800 | |
| chr17:39,695,905–39,696,636 | 284.5 kb | Distal (>10kb) Multiome | 499 | |
| chr17:39,699,516–39,700,527 | 280.9 kb | Distal (>10kb) Multiome | 528 | |
| chr17:39,730,039–39,730,906 | 250.3 kb | Distal (>10kb) Multiome | 886 | |
| chr17:39,739,067–39,739,915 | 241.3 kb | Distal (>10kb) Multiome | 648 | |
| chr17:39,740,384–39,740,910 | 240.1 kb | Distal (>10kb) Multiome | 513 | |
| chr17:39,753,811–39,754,996 | 226.4 kb | Distal (>10kb) Multiome | 1000 | |
| chr17:39,926,716–39,928,343 | 53.1 kb | Distal (>10kb) Multiome | 942 | |
| chr17:39,952,356–39,953,923 | 27.7 kb | Distal (>10kb) Multiome | 598 | |
| chr17:39,979,964–39,981,234 | 188 bp | At TSS Multiome | 1148 | |
| chr17:40,054,311–40,054,810 | 73.7 kb | Distal (>10kb) Multiome | 694 | |
| chr17:40,062,700–40,063,624 | 82.2 kb | Distal (>10kb) Multiome | 609 | |
| chr17:40,075,390–40,075,997 | 94.9 kb | Distal (>10kb) Multiome | 556 | |
| chr17:40,098,950–40,099,858 | 118.4 kb | Distal (>10kb) Multiome | 997 | |
| chr17:40,100,155–40,101,301 | 120.0 kb | Distal (>10kb) Multiome | 954 | |
| chr17:40,111,702–40,112,164 | 131.0 kb | Distal (>10kb) Multiome | 678 | |
| chr17:40,113,185–40,113,691 | 132.6 kb | Distal (>10kb) Multiome | 864 | |
| chr17:40,121,452–40,123,602 | 141.1 kb | Distal (>10kb) Multiome | 799 | |
| chr17:40,139,909–40,141,108 | 159.6 kb | Distal (>10kb) Multiome | 1121 | |
| chr17:40,177,152–40,178,398 | 196.7 kb | Distal (>10kb) Multiome | 329 | |
| chr17:40,191,326–40,192,022 | 211.0 kb | Distal (>10kb) Multiome | 588 | |
| chr17:40,218,712–40,219,963 | 238.6 kb | Distal (>10kb) Multiome | 901 |
Genomic view of the PSMD3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.