PSMD14

proteasome 26S subunit, non-ATPase 14 | POH1, Rpn11, pad1

This gene encodes a component of the 26S proteasome. The 26S proteasome is a large multiprotein complex that catalyzes the degradation of ubiquitinated intracellular proteins. The encoded protein is a component of the 19S regulatory cap complex of the 26S proteasome and mediates substrate deubiquitination. A pseudogene of this gene is also located on the long arm of chromosome 2. [provided by RefSeq, Feb 2012]

Developmental clusters: GC5

Biological processes 49 terms

K63-linked deubiquitinase activity (GO:0061578)K63-linked deubiquitinase activity (GO:0061578)cellular response to type I interferon (GO:0071357)cysteine-type deubiquitinase activity (GO:0004843)cytosol (GO:0005829)cytosol (GO:0005829)cytosolic proteasome complex (GO:0031597)double-strand break repair via homologous recombination (GO:0000724)double-strand break repair via nonhomologous end joining (GO:0006303)endopeptidase activator activity (GO:0061133)extracellular region (GO:0005576)ficolin-1-rich granule lumen (GO:1904813)metal-dependent deubiquitinase activity (GO:0140492)metal-dependent deubiquitinase activity (GO:0140492)metal-dependent deubiquitinase activity (GO:0140492)metal-dependent deubiquitinase activity (GO:0140492)metallopeptidase activity (GO:0008237)metallopeptidase activity (GO:0008237)nucleoplasm (GO:0005654)nucleoplasm (GO:0005654)nucleus (GO:0005634)nucleus (GO:0005634)peptidase activity (GO:0008233)proteasomal protein catabolic process (GO:0010498)proteasome accessory complex (GO:0022624)proteasome accessory complex (GO:0022624)proteasome binding (GO:0070628)proteasome binding (GO:0070628)proteasome complex (GO:0000502)proteasome complex (GO:0000502)proteasome complex (GO:0000502)proteasome regulatory particle, lid subcomplex (GO:0008541)proteasome regulatory particle, lid subcomplex (GO:0008541)proteasome-mediated ubiquitin-dependent protein catabolic process (GO:0043161)proteasome-mediated ubiquitin-dependent protein catabolic process (GO:0043161)protein K63-linked deubiquitination (GO:0070536)protein K63-linked deubiquitination (GO:0070536)protein binding (GO:0005515)protein deubiquitination (GO:0016579)regulation of macroautophagy (GO:0016241)regulation of proteasomal protein catabolic process (GO:0061136)regulation of proteasomal protein catabolic process (GO:0061136)response to ethanol (GO:0045471)response to oxidative stress (GO:0006979)retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum (GO:0006890)secretory granule lumen (GO:0034774)synaptic vesicle (GO:0008021)synaptic vesicle (GO:0008021)ubiquitin-dependent protein catabolic process (GO:0006511)

Expression (TPM)

TFs regulating PSMD14 0 TFs

Transcription factors with Perturb-seq knockdown data for PSMD14. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PSMD14 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to PSMD14

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PSMD14, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr2:161,159,952–161,161,374	148.0 kb	Distal (>10kb) Multiome	1083
chr2:161,237,151–161,239,873	69.6 kb	Distal (>10kb) Multiome	760
chr2:161,244,441–161,245,204	63.6 kb	Distal (>10kb) Multiome	383
chr2:161,307,935–161,309,054	17 bp	At TSS Multiome	1018
chr2:161,413,932–161,417,535	106.2 kb	Distal (>10kb) Multiome	691
chr2:161,417,732–161,419,279	110.4 kb	Distal (>10kb) Multiome	374
chr2:161,422,463–161,424,682	115.5 kb	Distal (>10kb) Multiome	296
chr2:161,426,467–161,428,505	119.8 kb	Distal (>10kb) Multiome	275

Genome Browser

Genomic view of the PSMD14 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.