The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. This gene encodes a member of the proteasome subunit S9 family that functions as a non-ATPase subunit of the 19S regulator and is phosphorylated by AMP-activated protein kinase. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jul 2012]
Transcription factors with Perturb-seq knockdown data for PSMD11. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PSMD11 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PSMD11, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:32,265,505–32,266,972 | 178.8 kb | Distal (>10kb) Multiome | 354 | |
| chr17:32,341,667–32,342,507 | 102.4 kb | Distal (>10kb) Multiome | 954 | |
| chr17:32,349,923–32,350,604 | 94.4 kb | Distal (>10kb) Multiome | 814 | |
| chr17:32,443,864–32,445,143 | 96 bp | At TSS Multiome | 867 | |
| chr17:32,483,367–32,483,985 | 39.2 kb | Distal (>10kb) Multiome | 306 | |
| chr17:32,486,205–32,487,756 | 42.3 kb | Distal (>10kb) Multiome | 682 | |
| chr17:32,518,898–32,520,031 | 75.0 kb | Distal (>10kb) Multiome | 385 |
Genomic view of the PSMD11 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.