PSMC5

proteasome 26S subunit, ATPase 5 | RPT6, S8, SUG-1, SUG1, TBP10, TRIP1, p45, p45/SUG

The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. In addition to participation in proteasome functions, this subunit may participate in transcriptional regulation since it has been shown to interact with the thyroid hormone receptor and retinoid X receptor-alpha. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]

Member of: DE-1 DE-1.19

Biological processes 48 terms

ATP binding (GO:0005524)ATP hydrolysis activity (GO:0016887)DNA-binding transcription factor binding (GO:0140297)TBP-class protein binding (GO:0017025)blood microparticle (GO:0072562)cellular response to type I interferon (GO:0071357)cytoplasm (GO:0005737)cytoplasm (GO:0005737)cytoplasmic vesicle (GO:0031410)cytosol (GO:0005829)cytosol (GO:0005829)cytosol (GO:0005829)cytosolic proteasome complex (GO:0031597)extracellular exosome (GO:0070062)general transcription initiation factor binding (GO:0140296)inclusion body (GO:0016234)membrane (GO:0016020)negative regulation of programmed cell death (GO:0043069)nuclear proteasome complex (GO:0031595)nucleoplasm (GO:0005654)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)plasma membrane (GO:0005886)positive regulation of DNA-templated transcription (GO:0045893)positive regulation of inclusion body assembly (GO:0090261)positive regulation of proteasomal protein catabolic process (GO:1901800)proteasomal protein catabolic process (GO:0010498)proteasome accessory complex (GO:0022624)proteasome accessory complex (GO:0022624)proteasome complex (GO:0000502)proteasome regulatory particle (GO:0005838)proteasome regulatory particle, base subcomplex (GO:0008540)proteasome-activating activity (GO:0036402)proteasome-activating activity (GO:0036402)proteasome-activating activity (GO:0036402)proteasome-mediated ubiquitin-dependent protein catabolic process (GO:0043161)proteasome-mediated ubiquitin-dependent protein catabolic process (GO:0043161)proteasome-mediated ubiquitin-dependent protein catabolic process (GO:0043161)protein binding (GO:0005515)regulation of proteasomal protein catabolic process (GO:0061136)regulation of transcription by RNA polymerase II (GO:0006357)response to oxidative stress (GO:0006979)signaling receptor binding (GO:0005102)synaptic vesicle (GO:0008021)synaptic vesicle (GO:0008021)thyrotropin-releasing hormone receptor binding (GO:0031531)transcription factor binding (GO:0008134)

Expression (TPM)

TFs regulating PSMC5 0 TFs

Transcription factors with Perturb-seq knockdown data for PSMC5. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PSMC5 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to PSMC5

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PSMC5, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr17:63,549,660–63,551,443	277.1 kb	Distal (>10kb) Multiome	1037
chr17:63,600,715–63,601,423	226.5 kb	Distal (>10kb) Multiome	1122
chr17:63,621,512–63,623,359	205.4 kb	Distal (>10kb) Multiome	956
chr17:63,698,705–63,701,428	127.3 kb	Distal (>10kb) Multiome	663
chr17:63,741,119–63,742,935	85.6 kb	Distal (>10kb) Multiome	1057
chr17:63,773,179–63,774,727	53.7 kb	Distal (>10kb) Multiome	1169
chr17:63,826,794–63,828,024	66 bp	At TSS Multiome	1008
chr17:63,834,919–63,835,138	7.5 kb	Proximal (<10kb)	307
chr17:63,841,547–63,843,442	15.5 kb	Distal (>10kb) Multiome	1203
chr17:63,848,836–63,849,566	21.8 kb	Distal (>10kb) Multiome	658
chr17:63,960,119–63,962,604	134.5 kb	Distal (>10kb) Multiome	445
chr17:63,998,051–63,998,826	170.9 kb	Distal (>10kb) Multiome	408

Genome Browser

Genomic view of the PSMC5 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.