The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. Proteolytic processing is required to generate a mature subunit. Expression of this gene is induced by gamma interferon, and this gene product replaces catalytic subunit 2 (proteasome beta 7 subunit) in the immunoproteasome. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for PSMB10. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PSMB10 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PSMB10, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:67,644,719–67,645,304 | 291.9 kb | Distal (>10kb) Multiome | 638 | |
| chr16:67,649,353–67,649,999 | 287.1 kb | Distal (>10kb) Multiome | 112 | |
| chr16:67,652,610–67,653,810 | 283.9 kb | Distal (>10kb) Multiome | 498 | |
| chr16:67,659,631–67,661,707 | 276.0 kb | Distal (>10kb) Multiome HiCAR | 962 | |
| chr16:67,666,180–67,667,235 | 270.3 kb | Distal (>10kb) Multiome HiCAR | 713 | |
| chr16:67,667,674–67,668,349 | 268.8 kb | Distal (>10kb) Multiome HiCAR | 628 | |
| chr16:67,718,772–67,720,138 | 217.5 kb | Distal (>10kb) Multiome | 866 | |
| chr16:67,806,066–67,807,386 | 130.1 kb | Distal (>10kb) Multiome | 914 | |
| chr16:67,816,404–67,816,888 | 120.1 kb | Distal (>10kb) Multiome | 690 | |
| chr16:67,833,426–67,834,269 | 103.0 kb | Distal (>10kb) Multiome | 838 | |
| chr16:67,841,337–67,843,276 | 94.8 kb | Distal (>10kb) Multiome | 927 | |
| chr16:67,846,090–67,847,897 | 90.1 kb | Distal (>10kb) Multiome | 1025 | |
| chr16:67,872,739–67,873,665 | 63.8 kb | Distal (>10kb) Multiome | 982 | |
| chr16:67,884,566–67,885,097 | 52.0 kb | Distal (>10kb) Multiome HiCAR | 264 | |
| chr16:67,892,898–67,893,885 | 43.7 kb | Distal (>10kb) Multiome | 867 | |
| chr16:67,928,548–67,928,789 | 7.0 kb | Proximal (<10kb) | 343 | |
| chr16:67,931,929–67,932,317 | 3.5 kb | Proximal (<10kb) | 50 | |
| chr16:67,935,189–67,936,596 | 1.1 kb | Proximal (<10kb) Multiome | 980 | |
| chr16:67,942,159–67,942,373 | 6.4 kb | Proximal (<10kb) | 269 | |
| chr16:67,963,746–67,964,209 | 27.1 kb | Distal (>10kb) Multiome | 161 | |
| chr16:67,968,087–67,969,341 | 31.8 kb | Distal (>10kb) Multiome | 861 | |
| chr16:67,993,130–67,993,736 | 56.5 kb | Distal (>10kb) Multiome | 790 | |
| chr16:68,022,490–68,023,556 | 86.3 kb | Distal (>10kb) Multiome | 958 | |
| chr16:68,084,205–68,086,133 | 148.3 kb | Distal (>10kb) Multiome | 1092 | |
| chr16:68,235,016–68,238,254 | 299.3 kb | Distal (>10kb) Multiome | 1055 |
Genomic view of the PSMB10 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.