PSMA7

proteasome 20S subunit alpha 7 | C6, HSPC, RC6-1, XAPC7

The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. This gene encodes a member of the peptidase T1A family that functions as a 20S core alpha subunit. The encoded protein interacts with the hepatitis B virus X protein and plays a role in regulating hepatitis C virus internal ribosome entry site (IRES) activity, an activity essential for viral replication. The encoded protein also plays a role in the cellular stress response by regulating hypoxia-inducible factor-1alpha. A pseudogene of this gene is located on the long arm of chromosome 9. [provided by RefSeq, Jul 2012]

Member of: DE-1 DE-1.35

Biological processes 56 terms

CD8-positive, alpha-beta T cell differentiation (GO:0043374)CD8-positive, alpha-beta T cell homeostasis (GO:0160165)DNA damage response (GO:0006974)DNA repair (GO:0006281)T-helper 1 cell differentiation (GO:0045063)T-helper 17 cell differentiation (GO:0072539)apoptotic process (GO:0006915)cellular response to type I interferon (GO:0071357)cytoplasm (GO:0005737)cytoplasm (GO:0005737)cytoplasm (GO:0005737)cytosol (GO:0005829)cytosol (GO:0005829)cytosol (GO:0005829)extracellular exosome (GO:0070062)flagellated sperm motility (GO:0030317)identical protein binding (GO:0042802)immune system process (GO:0002376)negative regulation of regulatory T cell differentiation (GO:0045590)nucleoplasm (GO:0005654)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)positive regulation of interleukin-2 production (GO:0032743)positive regulation of tumor necrosis factor production (GO:0032760)positive regulation of type II interferon production (GO:0032729)proteasomal protein catabolic process (GO:0010498)proteasomal protein catabolic process (GO:0010498)proteasomal ubiquitin-independent protein catabolic process (GO:0010499)proteasome complex (GO:0000502)proteasome complex (GO:0000502)proteasome core complex (GO:0005839)proteasome core complex (GO:0005839)proteasome core complex (GO:0005839)proteasome core complex, alpha-subunit complex (GO:0019773)proteasome core complex, alpha-subunit complex (GO:0019773)proteasome core complex, alpha-subunit complex (GO:0019773)proteasome core complex, alpha-subunit complex (GO:0019773)proteasome storage granule (GO:0034515)proteasome-mediated ubiquitin-dependent protein catabolic process (GO:0043161)proteasome-mediated ubiquitin-dependent protein catabolic process (GO:0043161)proteasome-mediated ubiquitin-dependent protein catabolic process (GO:0043161)protein binding (GO:0005515)protein catabolic process (GO:0030163)regulation of G1/S transition of mitotic cell cycle (GO:2000045)regulation of proteasomal protein catabolic process (GO:0061136)regulation of proteasomal protein catabolic process (GO:0061136)response to oxidative stress (GO:0006979)response to oxidative stress (GO:0006979)response to type II interferon (GO:0034341)structural constituent of proteasome (GO:0140756)synaptic vesicle (GO:0008021)thymic T cell selection (GO:0045061)ubiquitin-dependent protein catabolic process (GO:0006511)

Expression (TPM)

TFs regulating PSMA7 0 TFs

Transcription factors with Perturb-seq knockdown data for PSMA7. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PSMA7 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to PSMA7

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PSMA7, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr20:62,065,357–62,067,442	77.4 kb	Distal (>10kb) Multiome	841
chr20:62,121,331–62,123,419	21.2 kb	Distal (>10kb) Multiome	961
chr20:62,142,789–62,144,593	70 bp	At TSS Multiome	841
chr20:62,182,546–62,183,326	39.6 kb	Distal (>10kb) Multiome	1075
chr20:62,219,369–62,220,936	76.9 kb	Distal (>10kb) Multiome	599
chr20:62,237,918–62,239,210	94.9 kb	Distal (>10kb) Multiome	794
chr20:62,301,857–62,303,576	158.7 kb	Distal (>10kb) Multiome	1110
chr20:62,365,805–62,369,404	225.6 kb	Distal (>10kb) Multiome	960
chr20:62,386,553–62,387,309	243.6 kb	Distal (>10kb) Multiome	885
chr20:62,406,793–62,407,817	263.9 kb	Distal (>10kb) Multiome	935

Genome Browser

Genomic view of the PSMA7 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.