Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in chromatin remodeling. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2025]
Transcription factors with Perturb-seq knockdown data for PSKH2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PSKH2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PSKH2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:86,059,380–86,060,226 | 9.4 kb | Proximal (<10kb) | 24 | |
| chr8:86,063,309–86,064,635 | 5.0 kb | Proximal (<10kb) | 180 | |
| chr8:86,068,911–86,069,915 | at TSS | At TSS | 240 | |
| chr8:86,071,505–86,071,672 | 1.8 kb | Proximal (<10kb) | 24 | |
| chr8:86,072,815–86,073,392 | 3.1 kb | Proximal (<10kb) | 109 | |
| chr8:86,073,661–86,074,117 | 4.0 kb | Proximal (<10kb) | 24 |
Genomic view of the PSKH2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.