Involved in positive regulation of ERK1 and ERK2 cascade and positive regulation of glycolytic process. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for PRXL2C. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PRXL2C upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PRXL2C, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:96,383,184–96,383,893 | 271.7 kb | Distal (>10kb) Multiome | 519 | |
| chr9:96,416,915–96,419,539 | 238.0 kb | Distal (>10kb) Multiome | 1128 | |
| chr9:96,449,559–96,451,233 | 205.2 kb | Distal (>10kb) Multiome | 666 | |
| chr9:96,543,037–96,543,508 | 112.0 kb | Distal (>10kb) Multiome | 76 | |
| chr9:96,566,442–96,567,471 | 88.4 kb | Distal (>10kb) Multiome | 819 | |
| chr9:96,618,860–96,620,237 | 35.5 kb | Distal (>10kb) Multiome | 570 | |
| chr9:96,620,809–96,621,291 | 34.2 kb | Distal (>10kb) Multiome | 143 | |
| chr9:96,654,449–96,655,707 | 40 bp | At TSS Multiome | 706 | |
| chr9:96,686,688–96,687,337 | 31.6 kb | Distal (>10kb) Multiome | 253 | |
| chr9:96,777,772–96,778,352 | 122.7 kb | Distal (>10kb) Multiome | 632 | |
| chr9:96,854,007–96,854,748 | 199.2 kb | Distal (>10kb) Multiome | 699 | |
| chr9:96,875,314–96,876,157 | 220.6 kb | Distal (>10kb) Multiome | 643 |
Genomic view of the PRXL2C locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.