This gene belongs to the trypsin family of serine proteases and encodes anionic trypsinogen. It is part of a cluster of trypsinogen genes that are located within the T cell receptor beta locus. Enzymes of this family cleave peptide bonds that follow lysine or arginine residues. This protein is found at high levels in pancreatic juice and its upregulation is a characteristic feature of pancreatitis. This protein has also been found to activate pro-urokinase in ovarian tumors, suggesting a function in tumor invasion. In addition, this enzyme is able to cleave across the type II collagen triple helix in rheumatoid arthritis synovitis tissue, potentially participating in the degradation of type II collagen-rich cartilage matrix. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Jan 2015]
Transcription factors with Perturb-seq knockdown data for PRSS2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PRSS2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PRSS2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:142,748,805–142,749,672 | 21.7 kb | Distal (>10kb) Multiome | 74 | |
| chr7:142,760,137–142,760,448 | at TSS | At TSS | 32 | |
| chr7:142,770,332–142,771,391 | 101 bp | At TSS Multiome | 150 | |
| chr7:142,782,876–142,783,641 | 12.3 kb | Distal (>10kb) Multiome | 448 | |
| chr7:142,853,711–142,856,176 | 84.0 kb | Distal (>10kb) Multiome | 583 | |
| chr7:142,885,313–142,886,162 | 114.8 kb | Distal (>10kb) Multiome | 160 | |
| chr7:143,041,996–143,043,331 | 271.9 kb | Distal (>10kb) Multiome | 258 |
Genomic view of the PRSS2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.