This gene encodes a member of the trypsin family of serine proteases and contains a signal peptide, a proline-rich region, a Kringle domain, four scavenger receptor cysteine-rich domains, and a trypsin-like serine protease domain. The protein, sometimes referred to as neurotrypsin or motopsin, is secreted from neuronal cells and localizes to the synaptic cleft. Studies in mice show that this protein cleaves a protein, agrin, that is important for the formation and maintenance of exitatory synapses. Defects in this gene cause a form of autosomal recessive cognitive impairment (MRT1). [provided by RefSeq, Jul 2017]
Transcription factors with Perturb-seq knockdown data for PRSS12. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PRSS12 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PRSS12, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:118,174,834–118,176,016 | 177.4 kb | Distal (>10kb) Multiome | 184 | |
| chr4:118,265,324–118,266,279 | 87.3 kb | Distal (>10kb) Multiome | 210 | |
| chr4:118,278,030–118,279,632 | 74.3 kb | Distal (>10kb) Multiome | 1058 | |
| chr4:118,346,562–118,346,995 | 6.0 kb | Proximal (<10kb) | 31 | |
| chr4:118,351,851–118,353,862 | 33 bp | At TSS Multiome | 619 | |
| chr4:118,591,329–118,592,247 | 238.7 kb | Distal (>10kb) Multiome | 545 |
Genomic view of the PRSS12 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.