The protein encoded by this gene is a single-pass transmembrane protein containing an N-terminal gamma-carboxyglutamic acid (Gla) domain and tandem Pro/Leu-Pro-Xaa-Tyr (PY) motifs at its C-terminal end. The Gla domain is exposed on the cell surface while the PY motifs are cytoplasmic. The PY motifs of the encoded protein have been shown to interact with YAP1, a WW domain-containing protein. Therefore, it is thought that the encoded protein may be part of a signal transduction pathway. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015]
Transcription factors with Perturb-seq knockdown data for PRRG2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PRRG2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PRRG2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:49,337,997–49,340,482 | 242.2 kb | Distal (>10kb) Multiome | 612 | |
| chr19:49,361,283–49,362,837 | 219.8 kb | Distal (>10kb) Multiome | 553 | |
| chr19:49,362,970–49,364,306 | 217.7 kb | Distal (>10kb) Multiome | 616 | |
| chr19:49,403,611–49,404,247 | 177.4 kb | Distal (>10kb) Multiome | 305 | |
| chr19:49,432,343–49,432,785 | 148.8 kb | Distal (>10kb) Multiome | 103 | |
| chr19:49,436,149–49,436,821 | 144.9 kb | Distal (>10kb) Multiome | 248 | |
| chr19:49,441,067–49,441,861 | 139.9 kb | Distal (>10kb) Multiome | 223 | |
| chr19:49,442,072–49,444,054 | 138.4 kb | Distal (>10kb) Multiome | 914 | |
| chr19:49,451,347–49,452,239 | 129.5 kb | Distal (>10kb) Multiome | 764 | |
| chr19:49,452,723–49,453,850 | 128.0 kb | Distal (>10kb) Multiome | 847 | |
| chr19:49,476,063–49,476,551 | 105.0 kb | Distal (>10kb) Multiome | 244 | |
| chr19:49,487,027–49,488,279 | 93.9 kb | Distal (>10kb) Multiome | 964 | |
| chr19:49,495,613–49,496,661 | 85.2 kb | Distal (>10kb) Multiome | 919 | |
| chr19:49,500,403–49,501,353 | 80.7 kb | Distal (>10kb) Multiome | 405 | |
| chr19:49,512,565–49,513,700 | 68.3 kb | Distal (>10kb) Multiome | 655 | |
| chr19:49,527,651–49,528,221 | 53.4 kb | Distal (>10kb) Multiome | 354 | |
| chr19:49,533,232–49,534,476 | 47.3 kb | Distal (>10kb) Multiome | 534 | |
| chr19:49,555,629–49,557,180 | 25.2 kb | Distal (>10kb) Multiome | 294 | |
| chr19:49,580,125–49,580,813 | 760 bp | At TSS Multiome | 848 | |
| chr19:49,589,601–49,594,008 | 12.2 kb | Distal (>10kb) Multiome | 994 | |
| chr19:49,638,063–49,638,728 | 56.9 kb | Distal (>10kb) Multiome | 237 | |
| chr19:49,639,671–49,642,787 | 59.0 kb | Distal (>10kb) Multiome | 1067 | |
| chr19:49,664,165–49,665,096 | 83.2 kb | Distal (>10kb) Multiome | 679 | |
| chr19:49,665,345–49,666,430 | 84.5 kb | Distal (>10kb) Multiome | 721 | |
| chr19:49,672,105–49,672,787 | 91.0 kb | Distal (>10kb) Multiome | 625 | |
| chr19:49,676,058–49,678,754 | 95.6 kb | Distal (>10kb) Multiome | 1033 | |
| chr19:49,680,433–49,681,147 | 99.4 kb | Distal (>10kb) Multiome | 435 | |
| chr19:49,690,485–49,691,761 | 109.7 kb | Distal (>10kb) Multiome | 327 | |
| chr19:49,746,188–49,746,748 | 165.1 kb | Distal (>10kb) Multiome | 283 | |
| chr19:49,766,231–49,767,440 | 185.3 kb | Distal (>10kb) Multiome | 718 | |
| chr19:49,802,146–49,802,787 | 221.1 kb | Distal (>10kb) Multiome | 200 | |
| chr19:49,805,226–49,805,871 | 224.2 kb | Distal (>10kb) Multiome | 245 | |
| chr19:49,808,201–49,809,746 | 227.6 kb | Distal (>10kb) Multiome | 509 | |
| chr19:49,812,926–49,813,834 | 232.1 kb | Distal (>10kb) Multiome | 650 | |
| chr19:49,817,356–49,818,721 | 236.9 kb | Distal (>10kb) Multiome | 784 | |
| chr19:49,850,394–49,852,067 | 269.5 kb | Distal (>10kb) Multiome | 862 | |
| chr19:49,866,817–49,868,124 | 286.0 kb | Distal (>10kb) Multiome | 874 | |
| chr19:49,869,068–49,870,398 | 288.3 kb | Distal (>10kb) Multiome | 832 | |
| chr19:49,875,842–49,878,576 | 296.4 kb | Distal (>10kb) Multiome | 1153 |
Genomic view of the PRRG2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.