PRR7

proline rich 7, synaptic | MGC10772

Enables long-chain fatty acid binding activity; protein tyrosine kinase binding activity; and ubiquitin-like protein ligase binding activity. Involved in positive regulation of apoptotic process and regulation of transcription by RNA polymerase I. Located in several cellular components, including cytosol; nucleoplasm; and perinuclear region of cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Member of: DE-7

Biological processes 29 terms

T cell differentiation (GO:0030217)cytosol (GO:0005829)dendrite (GO:0030425)glutamatergic synapse (GO:0098978)long-chain fatty acid binding (GO:0036041)neuron projection (GO:0043005)nucleoplasm (GO:0005654)nucleus (GO:0005634)nucleus (GO:0005634)perinuclear region of cytoplasm (GO:0048471)perinuclear region of cytoplasm (GO:0048471)plasma membrane (GO:0005886)plasma membrane (GO:0005886)plasma membrane (GO:0005886)positive regulation of apoptotic process (GO:0043065)postsynapse to nucleus signaling pathway (GO:0099527)postsynapse to nucleus signaling pathway (GO:0099527)postsynaptic density (GO:0014069)postsynaptic density membrane (GO:0098839)postsynaptic density, intracellular component (GO:0099092)postsynaptic density, intracellular component (GO:0099092)postsynaptic membrane (GO:0045211)protein binding (GO:0005515)protein tyrosine kinase binding (GO:1990782)protein-containing complex binding (GO:0044877)regulation of transcription by RNA polymerase I (GO:0006356)regulation of transcription by RNA polymerase I (GO:0006356)synapse (GO:0045202)ubiquitin-like protein ligase binding (GO:0044389)

Expression (TPM)

TFs regulating PRR7 0 TFs

Transcription factors with Perturb-seq knockdown data for PRR7. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PRR7 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to PRR7

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PRR7, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr5:177,303,008–177,304,238	143.1 kb	Distal (>10kb) Multiome	850
chr5:177,309,549–177,310,172	137.0 kb	Distal (>10kb) Multiome	373
chr5:177,311,267–177,313,178	134.6 kb	Distal (>10kb) Multiome	798
chr5:177,351,374–177,352,243	94.9 kb	Distal (>10kb) Multiome	832
chr5:177,362,756–177,363,624	83.6 kb	Distal (>10kb) Multiome	479
chr5:177,366,082–177,368,548	79.6 kb	Distal (>10kb) Multiome	626
chr5:177,370,255–177,371,449	75.9 kb	Distal (>10kb) Multiome HiCAR	584
chr5:177,402,327–177,404,671	42.4 kb	Distal (>10kb) Multiome HiCAR	807
chr5:177,425,334–177,427,296	20.4 kb	Distal (>10kb) Multiome	982
chr5:177,446,196–177,448,203	40 bp	At TSS Multiome	826
chr5:177,453,910–177,456,838	8.7 kb	Proximal (<10kb) Multiome	1057
chr5:177,457,280–177,458,365	11.0 kb	Distal (>10kb) Multiome	321
chr5:177,472,252–177,474,487	25.9 kb	Distal (>10kb) Multiome	546
chr5:177,491,301–177,491,987	44.8 kb	Distal (>10kb) Multiome	522
chr5:177,494,661–177,498,477	48.8 kb	Distal (>10kb) Multiome	915
chr5:177,500,863–177,501,460	54.3 kb	Distal (>10kb) Multiome	378
chr5:177,516,515–177,517,551	70.3 kb	Distal (>10kb) Multiome	958
chr5:177,553,719–177,554,931	107.8 kb	Distal (>10kb) Multiome	671
chr5:177,591,993–177,592,765	145.4 kb	Distal (>10kb) Multiome	724
chr5:177,599,409–177,600,500	153.3 kb	Distal (>10kb) Multiome	871
chr5:177,607,310–177,608,120	160.8 kb	Distal (>10kb) Multiome	392

Genome Browser

Genomic view of the PRR7 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.