PRR3

proline rich 3 | CAT56, Em:AB014077.1, Em:AB023052.2

Enables RNA binding activity. [provided by Alliance of Genome Resources, Jul 2025]

Member of: DE-5 DE-5.29

Biological processes 8 terms

PTW/PP1 phosphatase complex (GO:0072357)RNA binding (GO:0003723)chromatin (GO:0000785)enzyme-substrate adaptor activity (GO:0140767)metal ion binding (GO:0046872)positive regulation of termination of RNA polymerase II transcription, poly(A)-coupled (GO:2000806)protein binding (GO:0005515)protein phosphatase inhibitor activity (GO:0004864)

Expression (TPM)

TFs regulating PRR3 0 TFs

Transcription factors with Perturb-seq knockdown data for PRR3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PRR3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to PRR3

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PRR3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr6:30,259,131–30,260,199	297.8 kb	Distal (>10kb) Multiome	475
chr6:30,325,606–30,327,611	230.3 kb	Distal (>10kb) Multiome	1043
chr6:30,344,843–30,345,715	212.1 kb	Distal (>10kb) Multiome	892
chr6:30,357,696–30,358,238	199.4 kb	Distal (>10kb) Multiome	207
chr6:30,466,230–30,466,713	90.8 kb	Distal (>10kb) Multiome	369
chr6:30,489,117–30,490,512	67.0 kb	Distal (>10kb) Multiome HiCAR	750
chr6:30,516,006–30,516,707	41.0 kb	Distal (>10kb) Multiome	739
chr6:30,555,407–30,557,765	671 bp	At TSS Multiome	1161
chr6:30,570,822–30,571,949	14.1 kb	Distal (>10kb) Multiome	1000
chr6:30,614,393–30,615,939	57.9 kb	Distal (>10kb) Multiome	837
chr6:30,616,770–30,618,155	60.2 kb	Distal (>10kb) Multiome	1072
chr6:30,626,560–30,627,206	69.5 kb	Distal (>10kb) Multiome	802
chr6:30,646,505–30,648,035	90.0 kb	Distal (>10kb) Multiome	961
chr6:30,672,571–30,673,266	115.7 kb	Distal (>10kb) Multiome	812
chr6:30,679,032–30,679,479	121.9 kb	Distal (>10kb) Multiome	603
chr6:30,686,268–30,688,032	129.9 kb	Distal (>10kb) Multiome	801
chr6:30,690,445–30,691,240	133.6 kb	Distal (>10kb) Multiome	644
chr6:30,716,986–30,717,874	160.2 kb	Distal (>10kb) Multiome	1059
chr6:30,719,428–30,720,577	162.9 kb	Distal (>10kb) Multiome	724
chr6:30,721,307–30,722,103	164.2 kb	Distal (>10kb) Multiome	872
chr6:30,725,731–30,726,564	168.9 kb	Distal (>10kb) Multiome	478
chr6:30,740,996–30,745,094	185.4 kb	Distal (>10kb) Multiome	1233
chr6:30,763,647–30,765,193	207.1 kb	Distal (>10kb) Multiome	850

Genome Browser

Genomic view of the PRR3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.