This gene encodes a phosphoribosyl pyrophosphate synthetase that plays a central role in the synthesis of purines and pyrimidines. The encoded protein catalyzes the synthesis of 5-phosphoribosyl 1-pyrophosphate from ATP and D-ribose 5-phosphate. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]
Transcription factors with Perturb-seq knockdown data for PRPS2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PRPS2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PRPS2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chrX:12,790,010–12,790,496 | 914 bp | At TSS | 19 | |
| chrX:12,790,978–12,792,312 | 55 bp | At TSS Multiome | 502 | |
| chrX:12,946,827–12,947,613 | 155.7 kb | Distal (>10kb) Multiome | 422 | |
| chrX:12,974,537–12,975,757 | 183.6 kb | Distal (>10kb) Multiome | 603 | |
| chrX:13,013,668–13,014,732 | 222.7 kb | Distal (>10kb) Multiome | 301 | |
| chrX:13,030,065–13,030,946 | 239.0 kb | Distal (>10kb) Multiome | 344 |
Genomic view of the PRPS2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.