Predicted to enable double-stranded RNA binding activity; protein kinase binding activity; and protein kinase inhibitor activity. Involved in renal system process. Located in extracellular exosome. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for PRKRIP1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PRKRIP1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PRKRIP1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:101,232,007–101,233,160 | 1131.3 kb | Distal (>10kb) Multiome HiCAR | 304 | |
| chr7:101,602,457–101,603,098 | 761.2 kb | Distal (>10kb) Multiome HiCAR | 367 | |
| chr7:102,248,441–102,249,220 | 115.0 kb | Distal (>10kb) Multiome | 131 | |
| chr7:102,285,837–102,288,098 | 77.0 kb | Distal (>10kb) Multiome HiCAR | 792 | |
| chr7:102,300,749–102,301,273 | 62.8 kb | Distal (>10kb) Multiome HiCAR | 175 | |
| chr7:102,363,388–102,364,334 | 86 bp | At TSS Multiome | 479 | |
| chr7:102,390,780–102,391,019 | 5.3 kb | Proximal (<10kb) | 349 | |
| chr7:102,395,663–102,396,959 | 32.3 kb | Distal (>10kb) Multiome | 874 | |
| chr7:102,404,654–102,404,865 | 8.3 kb | Proximal (<10kb) | 188 | |
| chr7:102,432,870–102,434,057 | 69.6 kb | Distal (>10kb) Multiome | 553 | |
| chr7:102,464,403–102,465,431 | 101.1 kb | Distal (>10kb) Multiome | 854 |
Genomic view of the PRKRIP1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.