The protein encoded by this gene is a member of the protein kinase C family of serine- and threonine-specific protein kinases. The encoded protein is activated by diacylglycerol and is both a tumor suppressor and a positive regulator of cell cycle progression. Also, this protein can positively or negatively regulate apoptosis. Defects in this gene are a cause of autoimmune lymphoproliferative syndrome. [provided by RefSeq, Aug 2017]
Transcription factors with Perturb-seq knockdown data for PRKCD. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PRKCD upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PRKCD, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:52,897,094–52,897,995 | 263.5 kb | Distal (>10kb) Multiome | 474 | |
| chr3:53,044,987–53,047,058 | 115.7 kb | Distal (>10kb) Multiome | 653 | |
| chr3:53,072,497–53,073,757 | 88.2 kb | Distal (>10kb) Multiome | 597 | |
| chr3:53,130,008–53,130,811 | 30.7 kb | Distal (>10kb) Multiome HiCAR | 781 | |
| chr3:53,159,514–53,159,768 | 1.4 kb | Proximal (<10kb) | 250 | |
| chr3:53,160,572–53,162,503 | 143 bp | At TSS Multiome | 627 | |
| chr3:53,216,604–53,217,511 | 55.8 kb | Distal (>10kb) Multiome | 92 | |
| chr3:53,219,753–53,220,316 | 58.9 kb | Distal (>10kb) Multiome | 367 | |
| chr3:53,254,585–53,256,437 | 94.9 kb | Distal (>10kb) Multiome | 773 | |
| chr3:53,269,991–53,270,526 | 109.1 kb | Distal (>10kb) Multiome | 744 | |
| chr3:53,347,016–53,348,084 | 186.5 kb | Distal (>10kb) Multiome | 1111 |
Genomic view of the PRKCD locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.