Predicted to enable DNA-binding transcription factor activity; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and chromatin binding activity. Involved in several processes, including negative regulation of cell growth; positive regulation of fibroblast apoptotic process; and regulation of DNA-templated transcription. Located in cytosol and nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for PRDM11. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PRDM11 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PRDM11, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:44,862,158–44,862,936 | 284.9 kb | Distal (>10kb) Multiome | 435 | |
| chr11:44,893,997–44,894,680 | 253.0 kb | Distal (>10kb) Multiome | 245 | |
| chr11:44,911,150–44,911,857 | 235.8 kb | Distal (>10kb) Multiome | 202 | |
| chr11:44,949,162–44,951,290 | 197.6 kb | Distal (>10kb) Multiome | 458 | |
| chr11:44,954,146–44,954,620 | 192.9 kb | Distal (>10kb) Multiome | 48 | |
| chr11:44,977,463–44,978,182 | 169.6 kb | Distal (>10kb) Multiome | 120 | |
| chr11:45,145,615–45,145,877 | 1.5 kb | Proximal (<10kb) | 80 | |
| chr11:45,146,509–45,147,702 | 121 bp | At TSS Multiome | 678 | |
| chr11:45,180,177–45,181,500 | 33.4 kb | Distal (>10kb) Multiome | 508 | |
| chr11:45,285,702–45,286,694 | 139.0 kb | Distal (>10kb) Multiome | 215 | |
| chr11:45,355,038–45,355,740 | 208.1 kb | Distal (>10kb) Multiome | 319 | |
| chr11:45,371,172–45,371,739 | 224.0 kb | Distal (>10kb) Multiome | 253 | |
| chr11:45,410,320–45,411,837 | 263.7 kb | Distal (>10kb) Multiome | 182 |
Genomic view of the PRDM11 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.