This gene is reported to be specifically expressed in prostate, rectum and distal colon. Sequence analysis suggests that it may play a regulatory role in the nucleus. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for PRAC1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PRAC1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PRAC1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:48,457,105–48,457,564 | 265.2 kb | Distal (>10kb) Multiome | 358 | |
| chr17:48,526,970–48,527,843 | 195.2 kb | Distal (>10kb) Multiome | 167 | |
| chr17:48,543,214–48,543,984 | 179.0 kb | Distal (>10kb) Multiome | 355 | |
| chr17:48,578,092–48,578,728 | 144.2 kb | Distal (>10kb) Multiome | 324 | |
| chr17:48,610,274–48,610,853 | 111.7 kb | Distal (>10kb) Multiome | 450 | |
| chr17:48,671,728–48,672,690 | 50.0 kb | Distal (>10kb) Multiome | 409 | |
| chr17:48,678,104–48,678,743 | 44.0 kb | Distal (>10kb) Multiome | 453 | |
| chr17:48,718,468–48,719,563 | 3.7 kb | Proximal (<10kb) Multiome | 164 | |
| chr17:48,719,708–48,720,337 | 2.5 kb | Proximal (<10kb) Multiome | 181 | |
| chr17:48,722,219–48,723,762 | 421 bp | At TSS Multiome | 220 | |
| chr17:48,724,560–48,724,774 | 2.0 kb | Proximal (<10kb) | 101 | |
| chr17:48,728,286–48,729,570 | 6.4 kb | Proximal (<10kb) Multiome | 376 | |
| chr17:48,816,754–48,817,592 | 94.7 kb | Distal (>10kb) Multiome | 589 | |
| chr17:48,830,670–48,831,519 | 108.5 kb | Distal (>10kb) Multiome | 838 | |
| chr17:48,891,910–48,893,540 | 170.1 kb | Distal (>10kb) Multiome | 1059 | |
| chr17:48,907,825–48,909,317 | 185.8 kb | Distal (>10kb) Multiome | 1011 | |
| chr17:48,944,483–48,945,203 | 222.3 kb | Distal (>10kb) Multiome | 1009 | |
| chr17:48,995,124–48,997,874 | 274.9 kb | Distal (>10kb) Multiome | 1057 | |
| chr17:49,013,253–49,014,714 | 291.5 kb | Distal (>10kb) Multiome | 480 | |
| chr17:49,022,149–49,022,993 | 300.1 kb | Distal (>10kb) Multiome | 306 | |
| chr17:49,968,328–49,969,629 | 1246.5 kb | Distal (>10kb) Multiome HiCAR | 702 |
Genomic view of the PRAC1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.