The protein encoded by this gene is a regulatory subunit of the serine/threonine-protein phosphatase 4 complex. In addition to being required for efficient DNA double strand break repair, this complex plays a role in organization of microtubules at centrosomes and processing of spliceosomal snRNPs. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015]
Transcription factors with Perturb-seq knockdown data for PPP4R2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PPP4R2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PPP4R2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:72,738,568–72,739,351 | 257.9 kb | Distal (>10kb) Multiome | 226 | |
| chr3:72,743,925–72,744,951 | 252.4 kb | Distal (>10kb) Multiome | 287 | |
| chr3:72,847,792–72,848,962 | 148.3 kb | Distal (>10kb) Multiome | 806 | |
| chr3:72,887,818–72,888,647 | 108.7 kb | Distal (>10kb) Multiome | 512 | |
| chr3:72,972,793–72,973,464 | 23.7 kb | Distal (>10kb) Multiome | 324 | |
| chr3:72,996,248–72,997,607 | 24 bp | At TSS Multiome | 749 | |
| chr3:73,153,802–73,155,115 | 157.6 kb | Distal (>10kb) Multiome | 60 | |
| chr3:73,253,909–73,255,284 | 257.8 kb | Distal (>10kb) Multiome | 165 |
Genomic view of the PPP4R2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.