PPP3CB
protein phosphatase 3 catalytic subunit beta | CALNA2, CNA2, PP2Bbeta, CALNB

Enables several functions, including calmodulin binding activity; calmodulin-dependent protein phosphatase activity; and protein phosphatase 2B binding activity. Involved in several processes, including calcineurin-NFAT signaling cascade; positive regulation of lysosome organization; and positive regulation of protein localization to nucleus. Located in cytoplasm. Part of calcineurin complex. Implicated in aortic valve stenosis. Biomarker of focal segmental glomerulosclerosis and schizophrenia. [provided by Alliance of Genome Resources, Jul 2025]

Member of: DE-2
Biological processes 63 terms
T cell activation (GO:0042110)T cell proliferation (GO:0042098)T-tubule (GO:0030315)Z disc (GO:0030018)axon extension (GO:0048675)calcineurin complex (GO:0005955)calcineurin complex (GO:0005955)calcineurin-NFAT signaling cascade (GO:0033173)calcineurin-NFAT signaling cascade (GO:0033173)calcineurin-mediated signaling (GO:0097720)calcineurin-mediated signaling (GO:0097720)calcineurin-mediated signaling (GO:0097720)calcium ion binding (GO:0005509)calcium-ion regulated exocytosis (GO:0017156)calcium-ion regulated exocytosis (GO:0017156)calmodulin binding (GO:0005516)calmodulin binding (GO:0005516)calmodulin binding (GO:0005516)calmodulin-dependent protein phosphatase activity (GO:0033192)calmodulin-dependent protein phosphatase activity (GO:0033192)calmodulin-dependent protein phosphatase activity (GO:0033192)calmodulin-dependent protein phosphatase activity (GO:0033192)calmodulin-dependent protein phosphatase activity (GO:0033192)cytoplasm (GO:0005737)cytoplasm (GO:0005737)cytoplasm (GO:0005737)cytosol (GO:0005829)cytosol (GO:0005829)cytosol (GO:0005829)dephosphorylation (GO:0016311)enzyme binding (GO:0019899)glutamatergic synapse (GO:0098978)hydrolase activity (GO:0016787)learning (GO:0007612)memory (GO:0007613)negative regulation of calcium ion import across plasma membrane (GO:1905949)negative regulation of signaling (GO:0023057)negative regulation of signaling (GO:0023057)nucleoplasm (GO:0005654)plasma membrane (GO:0005886)plasma membrane (GO:0005886)positive regulation of DNA-templated transcription (GO:0045893)positive regulation of calcineurin-NFAT signaling cascade (GO:0070886)positive regulation of calcium ion import across plasma membrane (GO:1905665)positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:0035774)positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:0035774)positive regulation of lysosome organization (GO:1905673)positive regulation of protein localization to nucleus (GO:1900182)positive regulation of transcription by RNA polymerase II (GO:0045944)protein binding (GO:0005515)protein dephosphorylation (GO:0006470)protein dephosphorylation (GO:0006470)protein dimerization activity (GO:0046983)protein phosphatase 2B binding (GO:0030346)protein phosphorylation (GO:0006468)protein serine/threonine phosphatase activity (GO:0004722)protein serine/threonine phosphatase activity (GO:0004722)regulation of insulin secretion (GO:0050796)regulation of synaptic plasticity (GO:0048167)regulation of synaptic vesicle endocytosis (GO:1900242)signal transduction (GO:0007165)skeletal muscle fiber development (GO:0048741)skeletal muscle fiber development (GO:0048741)
Expression (TPM)
PPP3CB — as a Regulated Gene

TFs regulating PPP3CB 0 TFs

Transcription factors with Perturb-seq knockdown data for PPP3CB. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PPP3CB upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

Data: Effect:
TF Mean coef Binding Outlier TF→Gene link

Elements linked to PPP3CB

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PPP3CB, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility Element Dist. to TSS Link type TFs
chr10:73,246,675–73,247,516 248.8 kb Distal (>10kb) Multiome 1023
chr10:73,252,167–73,253,067 243.3 kb Distal (>10kb) Multiome 929
chr10:73,358,383–73,358,977 137.2 kb Distal (>10kb) Multiome 468
chr10:73,413,302–73,414,453 82.0 kb Distal (>10kb) Multiome 938
chr10:73,495,235–73,496,398 78 bp At TSS Multiome 908
chr10:73,591,236–73,591,781 95.5 kb Distal (>10kb) Multiome 359
chr10:73,591,961–73,592,227 96.1 kb Distal (>10kb) Multiome 458
chr10:73,625,111–73,626,369 130.0 kb Distal (>10kb) Multiome 810
chr10:73,647,157–73,648,042 151.5 kb Distal (>10kb) Multiome HiCAR 238
chr10:73,730,165–73,730,854 234.5 kb Distal (>10kb) Multiome 823
chr10:73,741,689–73,742,673 246.2 kb Distal (>10kb) Multiome 190
chr10:73,743,801–73,744,894 248.3 kb Distal (>10kb) Multiome 962
chr10:73,771,782–73,773,237 276.8 kb Distal (>10kb) Multiome 918
chr10:73,781,688–73,782,352 286.0 kb Distal (>10kb) Multiome 721
chr10:73,785,180–73,785,869 289.5 kb Distal (>10kb) Multiome 745

Genome Browser

Genomic view of the PPP3CB locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.

chr10:73,236,675 – 73,795,869
Proximal 1 kb Distal 10 kb Multiome HiCAR ATAC-seq RNA-seq
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