The product of this gene belongs to the phosphatase 2A regulatory subunit B family. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a gamma isoform of the regulatory subunit B56 subfamily. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for PPP2R5C. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PPP2R5C upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PPP2R5C, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:101,559,493–101,562,183 | 248.5 kb | Distal (>10kb) Multiome | 329 | |
| chr14:101,563,518–101,564,657 | 245.9 kb | Distal (>10kb) Multiome | 127 | |
| chr14:101,688,293–101,688,782 | 121.3 kb | Distal (>10kb) Multiome | 137 | |
| chr14:101,705,720–101,706,457 | 103.8 kb | Distal (>10kb) Multiome | 326 | |
| chr14:101,726,532–101,727,181 | 83.1 kb | Distal (>10kb) Multiome | 45 | |
| chr14:101,760,098–101,762,537 | 48.2 kb | Distal (>10kb) Multiome | 852 | |
| chr14:101,808,059–101,808,248 | 1.6 kb | Proximal (<10kb) | 143 | |
| chr14:101,809,684–101,810,434 | 144 bp | At TSS Multiome | 701 | |
| chr14:101,947,631–101,948,934 | 138.3 kb | Distal (>10kb) Multiome | 984 | |
| chr14:101,963,949–101,965,702 | 154.6 kb | Distal (>10kb) Multiome | 798 | |
| chr14:102,046,172–102,046,761 | 236.6 kb | Distal (>10kb) Multiome | 326 | |
| chr14:102,086,286–102,088,835 | 277.3 kb | Distal (>10kb) Multiome | 1052 | |
| chr14:102,097,398–102,098,067 | 287.8 kb | Distal (>10kb) Multiome | 159 |
Genomic view of the PPP2R5C locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.