This gene encodes a regulatory subunit of the serine/threonine phosphatase, protein phosphatase 2. This protein is localized to both nuclear and cytoplasmic regions depending on cell cycle phase. Homozygous conditional knockout mice for this gene exhibit reduced numbers and impaired proliferation of immune system B cells. This protein may regulate the expression of the P-glycoprotein ATP-binding cassette transporter through its phosphatase activity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]
Transcription factors with Perturb-seq knockdown data for PPP2R3C. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PPP2R3C upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PPP2R3C, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:34,873,262–34,875,515 | 247.3 kb | Distal (>10kb) Multiome | 1146 | |
| chr14:34,981,885–34,983,443 | 139.8 kb | Distal (>10kb) Multiome | 1124 | |
| chr14:35,045,870–35,047,118 | 76.2 kb | Distal (>10kb) Multiome | 1047 | |
| chr14:35,113,020–35,113,353 | 8.7 kb | Proximal (<10kb) | 15 | |
| chr14:35,113,458–35,113,896 | 8.1 kb | Proximal (<10kb) | 44 | |
| chr14:35,121,659–35,123,040 | 480 bp | At TSS Multiome | 1148 | |
| chr14:35,291,742–35,292,860 | 169.8 kb | Distal (>10kb) Multiome | 994 | |
| chr14:35,336,559–35,337,059 | 214.4 kb | Distal (>10kb) Multiome | 773 | |
| chr14:35,341,371–35,342,254 | 219.3 kb | Distal (>10kb) Multiome | 604 | |
| chr14:35,346,777–35,348,358 | 225.4 kb | Distal (>10kb) Multiome | 829 | |
| chr14:35,355,863–35,357,022 | 233.8 kb | Distal (>10kb) Multiome | 595 | |
| chr14:35,403,426–35,405,915 | 282.4 kb | Distal (>10kb) Multiome HiCAR | 1102 |
Genomic view of the PPP2R3C locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.