The product of this gene belongs to the phosphatase 2 regulatory subunit B family. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes an alpha isoform of the regulatory subunit B55 subfamily. Alternatively spliced transcript variants have been described. [provided by RefSeq, Apr 2010]
Transcription factors with Perturb-seq knockdown data for PPP2R2A. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PPP2R2A upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PPP2R2A, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:26,003,482–26,004,046 | 287.8 kb | Distal (>10kb) Multiome | 51 | |
| chr8:26,045,104–26,047,131 | 246.2 kb | Distal (>10kb) Multiome | 416 | |
| chr8:26,064,268–26,065,352 | 226.7 kb | Distal (>10kb) Multiome | 128 | |
| chr8:26,290,938–26,292,152 | 124 bp | At TSS Multiome | 690 | |
| chr8:26,382,644–26,384,037 | 91.7 kb | Distal (>10kb) Multiome | 915 | |
| chr8:26,448,172–26,450,526 | 157.8 kb | Distal (>10kb) Multiome | 708 | |
| chr8:26,513,536–26,515,319 | 223.5 kb | Distal (>10kb) Multiome | 359 | |
| chr8:26,576,275–26,578,173 | 286.1 kb | Distal (>10kb) Multiome | 854 |
Genomic view of the PPP2R2A locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.