Predicted to enable protein phosphatase inhibitor activity. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for PPP1R37. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PPP1R37 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PPP1R37, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:44,800,231–44,800,829 | 292.5 kb | Distal (>10kb) Multiome | 508 | |
| chr19:44,807,965–44,809,338 | 285.1 kb | Distal (>10kb) Multiome | 652 | |
| chr19:44,844,448–44,848,668 | 248.4 kb | Distal (>10kb) Multiome | 1047 | |
| chr19:44,890,209–44,891,796 | 202.3 kb | Distal (>10kb) Multiome | 952 | |
| chr19:44,903,686–44,904,241 | 189.4 kb | Distal (>10kb) Multiome | 666 | |
| chr19:44,905,114–44,907,037 | 186.5 kb | Distal (>10kb) Multiome | 645 | |
| chr19:44,913,546–44,915,671 | 178.0 kb | Distal (>10kb) Multiome | 587 | |
| chr19:44,926,693–44,927,388 | 166.0 kb | Distal (>10kb) Multiome | 277 | |
| chr19:44,954,641–44,955,824 | 137.9 kb | Distal (>10kb) Multiome | 835 | |
| chr19:45,001,031–45,002,639 | 91.8 kb | Distal (>10kb) Multiome | 694 | |
| chr19:45,038,879–45,039,566 | 54.0 kb | Distal (>10kb) Multiome | 800 | |
| chr19:45,075,125–45,076,814 | 16.7 kb | Distal (>10kb) Multiome | 710 | |
| chr19:45,078,897–45,080,647 | 13.0 kb | Distal (>10kb) Multiome | 1012 | |
| chr19:45,091,042–45,093,574 | 164 bp | At TSS Multiome | 959 | |
| chr19:45,177,803–45,179,711 | 85.3 kb | Distal (>10kb) Multiome | 899 | |
| chr19:45,234,200–45,234,822 | 141.4 kb | Distal (>10kb) Multiome | 105 | |
| chr19:45,250,821–45,251,491 | 158.1 kb | Distal (>10kb) Multiome | 397 | |
| chr19:45,340,431–45,341,201 | 247.6 kb | Distal (>10kb) Multiome | 363 | |
| chr19:45,370,064–45,371,122 | 277.5 kb | Distal (>10kb) Multiome | 592 |
Genomic view of the PPP1R37 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.