Protein phosphatase-1 (PP1) is one of the main eukaryotic serine/threonine phosphatases. The protein encoded by this gene binds to the catalytic subunit of PP1, strongly inhibiting its activity. Ten related pseudogenes have been found throughout the human genome. Several splice variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015]
Transcription factors with Perturb-seq knockdown data for PPP1R2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PPP1R2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PPP1R2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:194,682,618–194,683,090 | 860.6 kb | Distal (>10kb) Multiome HiCAR | 506 | |
| chr3:194,685,606–194,686,409 | 857.5 kb | Distal (>10kb) Multiome HiCAR | 691 | |
| chr3:194,686,697–194,688,545 | 855.5 kb | Distal (>10kb) Multiome HiCAR | 426 | |
| chr3:195,259,295–195,260,886 | 283.1 kb | Distal (>10kb) Multiome HiCAR | 943 | |
| chr3:195,270,082–195,272,177 | 272.0 kb | Distal (>10kb) Multiome HiCAR | 1024 | |
| chr3:195,297,445–195,298,276 | 245.4 kb | Distal (>10kb) Multiome | 66 | |
| chr3:195,442,104–195,443,858 | 100.2 kb | Distal (>10kb) Multiome | 857 | |
| chr3:195,542,767–195,544,250 | 2 bp | At TSS Multiome | 765 | |
| chr3:195,806,205–195,806,743 | 263.2 kb | Distal (>10kb) Multiome | 119 |
Genomic view of the PPP1R2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.