The protein encoded by this gene is one of the three catalytic subunits of protein phosphatase 1 (PP1). PP1 is a serine/threonine specific protein phosphatase known to be involved in the regulation of a variety of cellular processes, such as cell division, glycogen metabolism, muscle contractility, protein synthesis, and HIV-1 viral transcription. Mouse studies suggest that PP1 functions as a suppressor of learning and memory. Two alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for PPP1CB. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PPP1CB upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PPP1CB, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:28,543,765–28,545,317 | 206.8 kb | Distal (>10kb) Multiome | 417 | |
| chr2:28,566,557–28,567,388 | 184.7 kb | Distal (>10kb) Multiome | 649 | |
| chr2:28,594,185–28,594,811 | 157.1 kb | Distal (>10kb) Multiome HiCAR | 431 | |
| chr2:28,684,184–28,684,644 | 67.3 kb | Distal (>10kb) Multiome | 193 | |
| chr2:28,751,058–28,752,579 | 151 bp | At TSS Multiome | 1022 | |
| chr2:28,810,346–28,811,351 | 59.1 kb | Distal (>10kb) Multiome | 393 | |
| chr2:28,869,665–28,870,899 | 118.7 kb | Distal (>10kb) Multiome | 1009 | |
| chr2:28,894,052–28,895,454 | 143.0 kb | Distal (>10kb) Multiome | 992 |
Genomic view of the PPP1CB locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.