The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase dephosphorylates, and negatively regulates the activities of, MAP kinases and MAP kinase kinases. It has been shown to inhibit the activation of p38 and JNK kinase cascades induced by environmental stresses. This phosphatase can also dephosphorylate cyclin-dependent kinases, and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to activate the expression of the tumor suppressor gene TP53/p53, which leads to G2/M cell cycle arrest and apoptosis. Three alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for PPM1A. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PPM1A upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PPM1A, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:60,091,167–60,092,522 | 157.2 kb | Distal (>10kb) Multiome | 1039 | |
| chr14:60,164,676–60,165,904 | 83.9 kb | Distal (>10kb) Multiome | 793 | |
| chr14:60,247,537–60,247,657 | 1.6 kb | Proximal (<10kb) | 21 | |
| chr14:60,247,765–60,250,615 | 40 bp | At TSS Multiome | 1091 | |
| chr14:60,331,221–60,332,142 | 82.6 kb | Distal (>10kb) Multiome | 515 | |
| chr14:60,485,178–60,486,252 | 236.7 kb | Distal (>10kb) Multiome | 378 | |
| chr14:60,508,535–60,510,247 | 259.8 kb | Distal (>10kb) Multiome | 245 | |
| chr14:60,514,579–60,516,786 | 265.8 kb | Distal (>10kb) Multiome | 517 |
Genomic view of the PPM1A locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.