The protein encoded by this gene is a component of desmosomes and of the epidermal cornified envelope in keratinocytes. The N-terminal domain of this protein interacts with the plasma membrane and its C-terminus interacts with intermediate filaments. Through its rod domain, this protein forms complexes with envoplakin. This protein may serve as a link between the cornified envelope and desmosomes as well as intermediate filaments. AKT1/PKB, a protein kinase mediating a variety of cell growth and survival signaling processes, is reported to interact with this protein, suggesting a possible role for this protein as a localization signal in AKT1-mediated signaling. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for PPL. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PPL upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PPL, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:4,693,016–4,694,663 | 243.5 kb | Distal (>10kb) Multiome | 730 | |
| chr16:4,733,836–4,735,221 | 202.7 kb | Distal (>10kb) Multiome | 858 | |
| chr16:4,766,728–4,767,628 | 169.9 kb | Distal (>10kb) Multiome | 795 | |
| chr16:4,768,438–4,769,162 | 168.3 kb | Distal (>10kb) Multiome | 677 | |
| chr16:4,801,836–4,803,175 | 134.8 kb | Distal (>10kb) Multiome | 743 | |
| chr16:4,846,559–4,848,209 | 89.7 kb | Distal (>10kb) Multiome | 803 | |
| chr16:4,936,143–4,937,673 | 142 bp | At TSS Multiome | 655 | |
| chr16:4,943,173–4,943,813 | 6.3 kb | Proximal (<10kb) Multiome | 609 | |
| chr16:4,957,489–4,958,782 | 21.0 kb | Distal (>10kb) Multiome | 802 | |
| chr16:5,010,592–5,011,132 | 73.7 kb | Distal (>10kb) Multiome | 136 | |
| chr16:5,033,461–5,034,081 | 96.7 kb | Distal (>10kb) Multiome | 932 | |
| chr16:5,071,693–5,072,259 | 134.8 kb | Distal (>10kb) Multiome | 940 | |
| chr16:5,097,069–5,098,979 | 160.9 kb | Distal (>10kb) Multiome | 638 | |
| chr16:5,213,262–5,213,748 | 276.3 kb | Distal (>10kb) Multiome | 34 |
Genomic view of the PPL locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.