This gene is a member of the cyclophilin family of peptidylprolyl isomerases. The cyclophilins are a highly conserved family, members of which play an important role in protein folding, immunosuppression by cyclosporin A, and infection of HIV-1 virions. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for PPIL4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PPIL4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PPIL4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:149,316,835–149,318,542 | 228.6 kb | Distal (>10kb) Multiome | 926 | |
| chr6:149,431,999–149,432,482 | 113.9 kb | Distal (>10kb) Multiome | 527 | |
| chr6:149,545,230–149,546,831 | 113 bp | At TSS Multiome | 1020 | |
| chr6:149,550,921–149,551,908 | 4.9 kb | Proximal (<10kb) | 48 | |
| chr6:149,565,581–149,567,238 | 20.2 kb | Distal (>10kb) Multiome | 1021 | |
| chr6:149,648,112–149,649,264 | 102.7 kb | Distal (>10kb) Multiome | 1051 | |
| chr6:149,708,994–149,710,258 | 163.6 kb | Distal (>10kb) Multiome | 141 | |
| chr6:149,717,353–149,718,457 | 172.0 kb | Distal (>10kb) Multiome | 1074 | |
| chr6:149,746,178–149,746,876 | 200.5 kb | Distal (>10kb) Multiome | 812 | |
| chr6:149,749,354–149,750,638 | 203.7 kb | Distal (>10kb) Multiome | 967 | |
| chr6:149,845,261–149,846,647 | 299.8 kb | Distal (>10kb) Multiome | 234 |
Genomic view of the PPIL4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.