This gene is a member of the cyclophilin family of peptidylprolyl isomerases. The cyclophilins are a highly conserved ubiquitous family, members of which play an important role in protein folding, immunosuppression by cyclosporin A, and infection of HIV-1 virions. This protein interacts with the proteinase inhibitor eglin c and is localized in the nucleus. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2015]
Transcription factors with Perturb-seq knockdown data for PPIL2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PPIL2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PPIL2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr22:21,567,510–21,568,436 | 98.3 kb | Distal (>10kb) Multiome | 951 | |
| chr22:21,628,821–21,630,259 | 35.9 kb | Distal (>10kb) Multiome | 1055 | |
| chr22:21,641,511–21,643,313 | 23.9 kb | Distal (>10kb) Multiome | 754 | |
| chr22:21,651,622–21,652,445 | 13.9 kb | Distal (>10kb) Multiome | 719 | |
| chr22:21,657,073–21,658,429 | 8.4 kb | Proximal (<10kb) Multiome | 802 | |
| chr22:21,665,721–21,666,577 | 134 bp | At TSS Multiome | 893 | |
| chr22:21,735,345–21,736,601 | 69.9 kb | Distal (>10kb) Multiome | 774 | |
| chr22:21,864,937–21,865,391 | 199.0 kb | Distal (>10kb) Multiome | 184 | |
| chr22:21,866,936–21,868,402 | 201.8 kb | Distal (>10kb) Multiome | 929 | |
| chr22:21,925,450–21,926,079 | 259.8 kb | Distal (>10kb) Multiome | 169 | |
| chr22:21,938,040–21,938,786 | 272.3 kb | Distal (>10kb) Multiome | 871 | |
| chr22:21,951,964–21,953,251 | 286.9 kb | Distal (>10kb) Multiome | 645 |
Genomic view of the PPIL2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.