The protein encoded by this gene is a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. This protein is a specific component of the complex that includes pre-mRNA processing factors PRPF3, PRPF4, and PRPF18, as well as U4/U5/U6 tri-snRNP. This protein has been shown to possess PPIase activity and may act as a protein chaperone that mediates the interactions between different proteins inside the spliceosome. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for PPIH. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PPIH upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PPIH, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:42,380,246–42,381,273 | 277.5 kb | Distal (>10kb) Multiome | 485 | |
| chr1:42,455,770–42,457,060 | 202.0 kb | Distal (>10kb) Multiome | 881 | |
| chr1:42,462,753–42,463,783 | 195.1 kb | Distal (>10kb) Multiome | 581 | |
| chr1:42,657,991–42,659,026 | 42 bp | At TSS Multiome | 952 | |
| chr1:42,681,723–42,683,347 | 24.0 kb | Distal (>10kb) Multiome | 924 | |
| chr1:42,739,796–42,740,734 | 82.0 kb | Distal (>10kb) Multiome | 365 | |
| chr1:42,765,982–42,767,804 | 108.9 kb | Distal (>10kb) Multiome | 899 | |
| chr1:42,816,354–42,817,722 | 158.9 kb | Distal (>10kb) Multiome | 721 | |
| chr1:42,845,973–42,847,060 | 188.2 kb | Distal (>10kb) Multiome | 723 | |
| chr1:42,923,882–42,925,144 | 266.2 kb | Distal (>10kb) Multiome | 878 | |
| chr1:42,957,739–42,959,536 | 299.7 kb | Distal (>10kb) Multiome | 943 |
Genomic view of the PPIH locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.