PPIG

peptidylprolyl isomerase G | CARS-Cyp, SCAF10, SRCyp

Enables peptidyl-prolyl cis-trans isomerase activity. Predicted to be involved in protein folding. Located in cytosol and nuclear speck. [provided by Alliance of Genome Resources, Jul 2025]

Member of: DE-1 DE-1.50 Developmental clusters: GC5

Biological processes 18 terms

RNA binding (GO:0003723)RNA splicing (GO:0008380)cyclosporin A binding (GO:0016018)cyclosporin A binding (GO:0016018)cytoplasm (GO:0005737)cytosol (GO:0005829)nuclear matrix (GO:0016363)nuclear speck (GO:0016607)nuclear speck (GO:0016607)nucleoplasm (GO:0005654)nucleus (GO:0005634)nucleus (GO:0005634)peptidyl-prolyl cis-trans isomerase activity (GO:0003755)peptidyl-prolyl cis-trans isomerase activity (GO:0003755)peptidyl-prolyl cis-trans isomerase activity (GO:0003755)protein binding (GO:0005515)protein folding (GO:0006457)protein folding (GO:0006457)

Expression (TPM)

TFs regulating PPIG 0 TFs

Transcription factors with Perturb-seq knockdown data for PPIG. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PPIG upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to PPIG

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PPIG, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr2:169,361,649–169,362,728	222.4 kb	Distal (>10kb) Multiome	485
chr2:169,363,554–169,365,015	219.8 kb	Distal (>10kb) Multiome	538
chr2:169,479,264–169,479,982	104.8 kb	Distal (>10kb) Multiome	907
chr2:169,573,179–169,574,073	10.5 kb	Distal (>10kb) Multiome	834
chr2:169,584,221–169,584,891	126 bp	At TSS Multiome	994
chr2:169,694,097–169,694,854	110.1 kb	Distal (>10kb) Multiome	898
chr2:169,733,252–169,734,532	149.6 kb	Distal (>10kb) Multiome	735
chr2:169,789,706–169,790,238	205.6 kb	Distal (>10kb) Multiome	539
chr2:169,798,658–169,799,453	214.6 kb	Distal (>10kb) Multiome	794
chr2:169,824,413–169,825,252	240.6 kb	Distal (>10kb) Multiome	946
chr2:169,827,076–169,828,199	243.1 kb	Distal (>10kb) Multiome	760

Genome Browser

Genomic view of the PPIG locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.