This transcribed pseudogene is related to PPIE (Gene ID: 10450). Expression of this pseudogene may be downregulated in non-small cell lung cancer (NSCLC). Differential DNA methylation of this locus may be associated with intellectual disability and bipolar disorder in human patients. [provided by RefSeq, Sep 2016]
Transcription factors with Perturb-seq knockdown data for PPIEL. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PPIEL upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PPIEL, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:39,276,096–39,276,654 | 283.0 kb | Distal (>10kb) Multiome | 93 | |
| chr1:39,394,478–39,395,744 | 163.7 kb | Distal (>10kb) Multiome | 295 | |
| chr1:39,408,101–39,409,740 | 150.5 kb | Distal (>10kb) Multiome | 760 | |
| chr1:39,490,877–39,492,177 | 67.8 kb | Distal (>10kb) Multiome | 495 | |
| chr1:39,576,409–39,577,232 | 17.5 kb | Distal (>10kb) Multiome | 683 | |
| chr1:39,609,639–39,610,339 | 50.5 kb | Distal (>10kb) Multiome | 387 | |
| chr1:39,632,749–39,633,322 | 73.7 kb | Distal (>10kb) Multiome | 174 | |
| chr1:39,639,353–39,640,336 | 80.4 kb | Distal (>10kb) Multiome | 503 | |
| chr1:39,691,164–39,691,639 | 132.1 kb | Distal (>10kb) Multiome | 333 | |
| chr1:39,701,474–39,702,144 | 142.5 kb | Distal (>10kb) Multiome | 352 | |
| chr1:39,738,639–39,739,177 | 179.5 kb | Distal (>10kb) Multiome | 534 | |
| chr1:39,788,434–39,789,609 | 229.7 kb | Distal (>10kb) Multiome | 548 |
Genomic view of the PPIEL locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.