The protein encoded by this gene is a member of the peptidyl-prolyl cis-trans isomerase (PPIase)) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. Similar to other PPIases, this protein can bind immunosuppressant cyclosporin A. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for PPIC. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PPIC upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PPIC, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:122,774,585–122,775,777 | 261.7 kb | Distal (>10kb) Multiome | 798 | |
| chr5:122,844,391–122,846,095 | 191.1 kb | Distal (>10kb) Multiome | 820 | |
| chr5:123,035,334–123,037,434 | 30 bp | At TSS Multiome | 780 | |
| chr5:123,088,080–123,091,125 | 53.6 kb | Distal (>10kb) Multiome | 570 | |
| chr5:123,093,515–123,094,439 | 57.2 kb | Distal (>10kb) Multiome | 126 | |
| chr5:123,097,777–123,100,237 | 63.0 kb | Distal (>10kb) Multiome | 307 |
Genomic view of the PPIC locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.