PPFIA4, or liprin-alpha-4, belongs to the liprin-alpha gene family. See liprin-alpha-1 (LIP1, or PPFIA1; MIM 611054) for background on liprins.[supplied by OMIM, Mar 2008]
Transcription factors with Perturb-seq knockdown data for PPFIA4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PPFIA4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PPFIA4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:202,806,787–202,808,806 | 218.0 kb | Distal (>10kb) Multiome | 869 | |
| chr1:202,810,279–202,811,748 | 215.6 kb | Distal (>10kb) Multiome | 933 | |
| chr1:202,818,850–202,819,302 | 207.5 kb | Distal (>10kb) Multiome | 40 | |
| chr1:202,860,760–202,862,216 | 164.9 kb | Distal (>10kb) Multiome | 695 | |
| chr1:202,888,353–202,889,540 | 137.5 kb | Distal (>10kb) Multiome | 894 | |
| chr1:202,926,591–202,927,689 | 99.3 kb | Distal (>10kb) Multiome | 1072 | |
| chr1:202,957,716–202,958,953 | 68.1 kb | Distal (>10kb) Multiome | 787 | |
| chr1:202,966,422–202,967,948 | 59.1 kb | Distal (>10kb) Multiome | 536 | |
| chr1:203,005,211–203,007,890 | 20.9 kb | Distal (>10kb) Multiome | 874 | |
| chr1:203,026,091–203,027,571 | 15 bp | At TSS Multiome | 771 | |
| chr1:203,075,525–203,076,284 | 49.5 kb | Distal (>10kb) Multiome | 165 | |
| chr1:203,117,633–203,118,111 | 91.4 kb | Distal (>10kb) Multiome | 344 | |
| chr1:203,127,495–203,128,610 | 101.8 kb | Distal (>10kb) Multiome | 317 | |
| chr1:203,267,310–203,267,938 | 241.1 kb | Distal (>10kb) Multiome | 432 | |
| chr1:203,273,131–203,273,728 | 246.8 kb | Distal (>10kb) Multiome | 579 | |
| chr1:203,290,403–203,291,005 | 264.1 kb | Distal (>10kb) Multiome | 474 | |
| chr1:203,304,867–203,306,858 | 278.9 kb | Distal (>10kb) Multiome | 964 | |
| chr1:203,306,959–203,308,132 | 281.4 kb | Distal (>10kb) Multiome | 305 | |
| chr1:203,320,713–203,321,472 | 294.5 kb | Distal (>10kb) Multiome | 331 |
Genomic view of the PPFIA4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.