Predicted to enable protein kinase binding activity. Predicted to be a structural constituent of postsynaptic actin cytoskeleton. Predicted to be involved in axonogenesis and cell motility. Located in blood microparticle and extracellular exosome. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for POTEF. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = POTEF upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of POTEF, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:129,877,126–129,878,386 | 251.5 kb | Distal (>10kb) Multiome | 356 | |
| chr2:129,923,163–129,924,117 | 205.6 kb | Distal (>10kb) Multiome | 183 | |
| chr2:130,129,284–130,129,709 | 62 bp | At TSS | 50 | |
| chr2:130,144,783–130,145,418 | 15.9 kb | Distal (>10kb) Multiome | 89 | |
| chr2:130,181,118–130,182,559 | 52.7 kb | Distal (>10kb) Multiome | 790 | |
| chr2:130,288,447–130,288,984 | 159.5 kb | Distal (>10kb) Multiome | 232 | |
| chr2:130,327,383–130,328,425 | 198.7 kb | Distal (>10kb) Multiome | 215 | |
| chr2:130,336,899–130,337,857 | 208.1 kb | Distal (>10kb) Multiome | 861 | |
| chr2:130,341,623–130,343,538 | 213.5 kb | Distal (>10kb) Multiome | 1109 | |
| chr2:130,355,375–130,356,704 | 226.8 kb | Distal (>10kb) Multiome | 816 | |
| chr2:130,371,871–130,373,243 | 243.3 kb | Distal (>10kb) Multiome | 651 | |
| chr2:130,391,075–130,391,923 | 262.3 kb | Distal (>10kb) Multiome | 609 |
Genomic view of the POTEF locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.