This gene encodes one of the protein subunits of the small nucleolar ribonucleoprotein complexes: the endoribonuclease for mitochondrial RNA processing complex and the ribonuclease P complex. The encoded protein is localized to the nucleus and associates directly with the RNA component of these complexes. This protein is involved in processing of precursor RNAs. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2009]
Transcription factors with Perturb-seq knockdown data for POP4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = POP4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of POP4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:28,391,818–28,392,831 | 1214.0 kb | Distal (>10kb) Multiome HiCAR | 207 | |
| chr19:28,393,507–28,394,356 | 1212.2 kb | Distal (>10kb) Multiome HiCAR | 184 | |
| chr19:28,915,618–28,916,367 | 690.3 kb | Distal (>10kb) Multiome HiCAR | 42 | |
| chr19:29,528,180–29,529,621 | 77.7 kb | Distal (>10kb) Multiome | 401 | |
| chr19:29,529,766–29,530,718 | 76.0 kb | Distal (>10kb) Multiome | 175 | |
| chr19:29,605,720–29,606,615 | 111 bp | At TSS Multiome | 901 | |
| chr19:29,610,433–29,610,904 | 4.4 kb | Proximal (<10kb) Multiome | 320 | |
| chr19:29,665,021–29,667,200 | 59.1 kb | Distal (>10kb) Multiome | 621 | |
| chr19:29,714,800–29,715,683 | 109.0 kb | Distal (>10kb) Multiome | 726 | |
| chr19:29,724,045–29,724,626 | 118.1 kb | Distal (>10kb) Multiome | 189 | |
| chr19:29,759,946–29,760,434 | 154.0 kb | Distal (>10kb) Multiome | 502 | |
| chr19:29,811,175–29,812,847 | 205.5 kb | Distal (>10kb) Multiome | 705 | |
| chr19:29,843,949–29,845,909 | 238.6 kb | Distal (>10kb) Multiome | 804 | |
| chr19:29,872,251–29,872,744 | 266.1 kb | Distal (>10kb) Multiome | 90 | |
| chr19:29,872,961–29,874,087 | 267.3 kb | Distal (>10kb) Multiome | 469 |
Genomic view of the POP4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.