This gene appears to have resulted from a fusion of DNA sequences derived from 2 distinct loci, specifically through the duplication of two internal exons from the POM121 gene and four 3' exons from the ZP3 gene. The 5' end of this gene is similar to the 5` coding region of the POM121 gene which encodes an integral nuclear pore membrane protein. However, the protein encoded by this gene lacks the nuclear pore localization motif. The 3' end of this gene is similar to the last 4 exons of the zona pellucida glycoprotein 3 (ZP3) gene and the encoded protein retains one zona pellucida domain. Multiple protein isoforms are encoded by transcript variants of this gene. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for POMZP3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = POMZP3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of POMZP3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:76,358,237–76,359,989 | 268.0 kb | Distal (>10kb) Multiome | 1036 | |
| chr7:76,379,650–76,380,602 | 247.2 kb | Distal (>10kb) Multiome | 853 | |
| chr7:76,392,882–76,394,121 | 234.0 kb | Distal (>10kb) Multiome | 932 | |
| chr7:76,395,928–76,396,741 | 231.1 kb | Distal (>10kb) Multiome | 152 | |
| chr7:76,397,187–76,397,970 | 229.7 kb | Distal (>10kb) Multiome | 496 | |
| chr7:76,409,261–76,409,956 | 217.5 kb | Distal (>10kb) Multiome | 281 | |
| chr7:76,510,075–76,510,721 | 116.9 kb | Distal (>10kb) Multiome | 201 | |
| chr7:76,548,975–76,549,826 | 78.0 kb | Distal (>10kb) Multiome HiCAR | 505 | |
| chr7:77,121,873–77,122,882 | 495.2 kb | Distal (>10kb) Multiome HiCAR | 516 |
Genomic view of the POMZP3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.