Predicted to enable nuclear localization sequence binding activity. Predicted to be a structural constituent of nuclear pore. Predicted to be involved in RNA export from nucleus and protein import into nucleus. Located in nuclear membrane and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for POM121C. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = POM121C upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of POM121C, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:75,486,016–75,486,644 | 51 bp | At TSS Multiome | 434 | |
| chr7:75,527,536–75,528,568 | 41.9 kb | Distal (>10kb) Multiome HiCAR | 667 | |
| chr7:75,531,374–75,531,886 | 45.4 kb | Distal (>10kb) Multiome | 161 | |
| chr7:75,546,305–75,547,063 | 60.3 kb | Distal (>10kb) Multiome | 150 | |
| chr7:75,638,467–75,640,092 | 153.4 kb | Distal (>10kb) Multiome | 654 | |
| chr7:75,738,406–75,739,915 | 252.9 kb | Distal (>10kb) Multiome | 795 | |
| chr7:75,778,655–75,779,512 | 292.8 kb | Distal (>10kb) Multiome | 54 | |
| chr7:75,780,667–75,781,151 | 294.5 kb | Distal (>10kb) Multiome | 106 |
Genomic view of the POM121C locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.