POLR3C

RNA polymerase III subunit C | C82, RPC3, RPC62

Enables single-stranded DNA binding activity. Involved in positive regulation of innate immune response and positive regulation of interferon-beta production. Located in nucleoplasm. Part of RNA polymerase III complex. [provided by Alliance of Genome Resources, Jul 2025]

Member of: DE-5

Biological processes 21 terms

DNA binding (GO:0003677)DNA-directed RNA polymerase activity (GO:0003899)DNA-templated transcription (GO:0006351)RNA polymerase III complex (GO:0005666)RNA polymerase III complex (GO:0005666)RNA polymerase III complex (GO:0005666)RNA polymerase III complex (GO:0005666)cytosol (GO:0005829)nucleoplasm (GO:0005654)nucleoplasm (GO:0005654)nucleus (GO:0005634)nucleus (GO:0005634)positive regulation of innate immune response (GO:0045089)positive regulation of interferon-beta production (GO:0032728)protein binding (GO:0005515)regulation of transcription by RNA polymerase III (GO:0006359)single-stranded DNA binding (GO:0003697)single-stranded DNA binding (GO:0003697)termination of RNA polymerase III transcription (GO:0006386)transcription by RNA polymerase III (GO:0006383)transcription initiation at RNA polymerase III promoter (GO:0006384)

Expression (TPM)

TFs regulating POLR3C 0 TFs

Transcription factors with Perturb-seq knockdown data for POLR3C. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = POLR3C upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to POLR3C

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of POLR3C, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr1:145,607,803–145,608,364	216.2 kb	Distal (>10kb) Multiome	205
chr1:145,707,296–145,708,738	116.1 kb	Distal (>10kb) Multiome	511
chr1:145,720,881–145,721,650	102.9 kb	Distal (>10kb) Multiome	548
chr1:145,823,605–145,824,539	126 bp	At TSS Multiome	899
chr1:145,845,315–145,846,128	21.5 kb	Distal (>10kb) Multiome	750
chr1:145,858,348–145,860,193	35.8 kb	Distal (>10kb) Multiome	828
chr1:145,885,653–145,886,460	61.9 kb	Distal (>10kb) Multiome	327
chr1:145,891,718–145,892,684	67.9 kb	Distal (>10kb) Multiome	738
chr1:145,918,087–145,919,947	94.7 kb	Distal (>10kb) Multiome	724
chr1:145,926,848–145,927,896	103.3 kb	Distal (>10kb) Multiome	890
chr1:145,932,283–145,933,321	108.6 kb	Distal (>10kb) Multiome	308
chr1:145,957,545–145,958,280	133.8 kb	Distal (>10kb) Multiome	631
chr1:145,960,287–145,961,311	136.5 kb	Distal (>10kb) Multiome	498
chr1:145,964,302–145,964,971	140.4 kb	Distal (>10kb) Multiome	662
chr1:145,978,977–145,980,010	155.3 kb	Distal (>10kb) Multiome	689
chr1:145,996,493–145,997,058	172.5 kb	Distal (>10kb) Multiome	911
chr1:146,035,364–146,036,312	211.5 kb	Distal (>10kb) Multiome	845
chr1:146,036,931–146,039,723	212.9 kb	Distal (>10kb) Multiome	1048
chr1:146,051,092–146,052,696	228.0 kb	Distal (>10kb) Multiome	1182

Genome Browser

Genomic view of the POLR3C locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.