The protein encoded by this gene is the catalytic component of RNA polymerase III, which synthesizes small RNAs. The encoded protein also acts as a sensor to detect foreign DNA and trigger an innate immune response. [provided by RefSeq, Aug 2011]
Transcription factors with Perturb-seq knockdown data for POLR3A. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = POLR3A upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of POLR3A, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:77,846,603–77,847,343 | 182.6 kb | Distal (>10kb) Multiome | 348 | |
| chr10:77,877,430–77,878,558 | 151.6 kb | Distal (>10kb) Multiome | 354 | |
| chr10:77,889,322–77,889,884 | 139.9 kb | Distal (>10kb) Multiome | 368 | |
| chr10:77,925,988–77,927,324 | 102.9 kb | Distal (>10kb) Multiome | 571 | |
| chr10:77,949,053–77,949,566 | 80.2 kb | Distal (>10kb) Multiome | 366 | |
| chr10:78,028,918–78,030,205 | 95 bp | At TSS Multiome | 902 | |
| chr10:78,033,398–78,034,359 | 4.3 kb | Proximal (<10kb) Multiome | 879 | |
| chr10:78,047,166–78,047,758 | 18.0 kb | Distal (>10kb) Multiome | 354 | |
| chr10:78,293,071–78,293,893 | 264.0 kb | Distal (>10kb) Multiome | 141 | |
| chr10:78,302,541–78,304,028 | 273.9 kb | Distal (>10kb) Multiome | 902 |
Genomic view of the POLR3A locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.