POLR2J

RNA polymerase II subunit J | POLR2J1, RPB11, RPB11A, RPB11m, hRPB14

This gene encodes a subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. The product of this gene exists as a heterodimer with another polymerase subunit; together they form a core subassembly unit of the polymerase. Two similar genes are located nearby on chromosome 7q22.1 and a pseudogene is found on chromosome 7p13. [provided by RefSeq, Jul 2008]

Member of: DE-1 DE-1.36

Biological processes 19 terms

DNA binding (GO:0003677)DNA-directed RNA polymerase activity (GO:0003899)DNA-directed RNA polymerase activity (GO:0003899)DNA-directed RNA polymerase activity (GO:0003899)DNA-templated transcription (GO:0006351)LRR domain binding (GO:0030275)RNA polymerase II, core complex (GO:0005665)RNA polymerase II, core complex (GO:0005665)RNA polymerase II, core complex (GO:0005665)nucleoplasm (GO:0005654)nucleus (GO:0005634)nucleus (GO:0005634)protein binding (GO:0005515)protein dimerization activity (GO:0046983)transcription by RNA polymerase II (GO:0006366)transcription by RNA polymerase II (GO:0006366)transcription by RNA polymerase II (GO:0006366)transcription elongation by RNA polymerase II (GO:0006368)transcription initiation at RNA polymerase II promoter (GO:0006367)

Expression (TPM)

TFs regulating POLR2J 0 TFs

Transcription factors with Perturb-seq knockdown data for POLR2J. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = POLR2J upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to POLR2J

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of POLR2J, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr7:102,248,441–102,249,220	230.1 kb	Distal (>10kb) Multiome	131
chr7:102,285,837–102,288,098	192.1 kb	Distal (>10kb) Multiome	792
chr7:102,300,749–102,301,273	177.8 kb	Distal (>10kb) Multiome	175
chr7:102,363,388–102,364,334	115.1 kb	Distal (>10kb) Multiome	479
chr7:102,395,663–102,396,959	82.7 kb	Distal (>10kb) Multiome	874
chr7:102,432,870–102,434,057	45.5 kb	Distal (>10kb) Multiome	553
chr7:102,464,403–102,465,431	14.0 kb	Distal (>10kb) Multiome	854
chr7:102,748,441–102,749,501	269.9 kb	Distal (>10kb) Multiome	433

Genome Browser

Genomic view of the POLR2J locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.